Search for European Projects

28 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Combatting Bacterial Resistance in Europe - Molecules against Gram Negative Infections (COMBACTE-MAGNET)

Start date: Jan 1, 2015, End date: Dec 31, 2021,

Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte ...
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 44

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Tackling secondhand tobacco smoke and e-cigarette emissions: exposure assessment, novel interventions, impact on lung diseases and economic burden in diverse European populations. The TackSHS Project. (TackSHS)

Start date: Nov 1, 2015, End date: Oct 31, 2019,

"Exposure to secondhand tobacco smoke (SHS) has been classified as a "Group 1" carcinogen (known human carcinogen) by the International Agency for Research on Cancer and has been shown to have adverse health effects on adults and children, including heart disease and respiratory disorders. Electronic cigarettes (e-cigarettes), the most common “electronic nicotine delivery system”, have irrupted i ...
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 11

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Screening for Chronic Kidney Disease (CKD) among Older People across Europe (SCOPE) (SCOPE)

Start date: May 1, 2015, End date: Apr 30, 2019,

Chronic kidney disease (CKD) is an important public health problem worldwide, especially in older people. Indeed, population aging in industrialized countries is accompanied by an increase in the prevalence of CKD and its complications. Although its prevalence and the importance of an early diagnosis to prevent complications such as end-renal stage disease (ESRD), screening programme in Europe are ...
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 11

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Diagnostic Imaging Strategies for Patients with Stable Chest Pain and Intermediate Risk of Coronary Artery Disease: Comparative Effectiveness Research of Existing Technologies (DISCHARGE)

Start date: Feb 1, 2014, End date: Jan 31, 2019,

Coronary artery disease (CAD) is the leading cause of death in high-income countries. Invasive coronary angiography (ICA) is the reference standard for the diagnosis of CAD and allows immediate therapy. However, only 40% of patients undergoing ICA actually have obstructive CAD and ICA has relatively rare but considerable risks. Coronary computed tomography (CT) is the most accurate diagnostic test ...
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 38

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Phase I/II Gene Therapy Trial of Fanconi anemia patients with a new Orphan Drug consisting of a lentiviral vector carrying the FANCA gene: A Coordinated International Action (EUROFANCOLEN)

Start date: Jan 1, 2013, End date: Dec 31, 2017,

Fanconi anemia (FA) is a rare inherited syndrome characterized by the early development of bone marrow failure and increasing predisposition to cancer with age. Allogeneic hematopoietic cell transplantation (alloHCT) is the only curative therapy for hematopoietic manifestations of FA, although associated with complications arising from myeloablation, graft versus host disease and increased inciden ...
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 13

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Scalable, point-of-care and label free microarray platform for rapid detection of Sepsis (RAIS)

Start date: Jan 1, 2015, End date: Dec 31, 2017,

The diagnosis and management of acute Sepsis is a critical area where fast and accurate results can translate into life changing health outcomes for individuals. The overall aim of RAIS is to develop a new point-of-care label-free microarray platform and validate it for quantifying levels of specific Sepsis’ biomarkers. The approach uses a novel interferometric technique ultimately capable of prov ...
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 9

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Personalized minimization of immunosuppression after solid organ transplantation by biomarker-driven stratification of patients to improve long-term outcome and health-economic data of transplantation (BIO-DrIM)

Start date: Nov 1, 2012, End date: Oct 31, 2017,

Organ transplantation has emerged as the “gold standard” therapy for end-stage organ failure. Incomplete control of chronic allograft injury but also the adverse effects of long-term immunosuppression (IS) continue to challenge the long-term success of transplantation. The paradigm is shifting from increasing “net”-IS by novel drugs to the concept of minimizing long-term IS as early as possible. H ...
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 17

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The effect of intracoronary reinfusion of bone marrow-derived mononuclear cells (BM-MNC) on all-cause mortality in acute myocardial infarction (BAMI)

Start date: Nov 1, 2011, End date: Oct 31, 2017,

Although the long term prognosis of patients suffering acute myocardial infarction (AMI) has improved since the introduction of reperfusion therapies and primary angioplasty, the 1 year mortality of patients with AMI and resultant left ventricular systolic dysfunction (LVSD) is still as high as 13%. A major reason for the high morbidity and mortality is that the heart has an inadequate regenerativ ...
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 23

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Adaptive and innovative Radiation Treatment FOR improving Cancer patients treatment outcomE (ARTFORCE)

Start date: Apr 1, 2011, End date: Sep 30, 2017,

...tments and redistribution of dose.3 decrease community costs by reserving expensive treatments for those who will benefit.This will be studied in randomized phase II clinical trials in top European institutes, followed by phase III trials outside this proposal.
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 14

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Defining the role of xeno-directed and autoimmune events in patients receiving animal-derived bioprosthetic heart valves (TRANSLINK)

Start date: Sep 1, 2013, End date: Aug 31, 2017,

TRANSLINK is a project devoted to assessing the mid-to long-term risk factors and improve the outcome of animal (bovine/porcine)-derived Bioprosthetic Heart Valve (BHV) implants. 300,000 patients/year benefit from BHV, a major healthcare problem (second most frequent cardiac surgery). BHV clinical outcome suffers from late dysfunctions restricting their application to older recipients. Based on a ...
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 14

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Benznidazol and Triazol REsearch group for Nanomedicine and Innovation on Chagas diseasE (BERENICE)

Start date: Sep 1, 2012, End date: Aug 31, 2017,

...ransfer issues, such as scale-up of the corresponding SUVs preparation methodology and its implementation at industrial scale.Apart from including stong participation from endemic countries's institutions, the consortium also involves private companies, thus enabling the participation of all the key actors of the chain to confront and control better Chagas disease. The innovative approach, through ...
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 10

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Development of a universal influenza vaccine based on tandem core technology (FLUTCORE)

Start date: Sep 1, 2013, End date: Mar 31, 2017,

"FLUTCORE will develop a novel universal influenza A virus (IAV) vaccine based on the tandem core vaccine platform. Recent influenza pandemics have emphasized the urgent need for better vaccines that are reactive with multiple IAV subtypes and that are no longer dependent on intimate knowledge of the prevalent virus. We propose to replace the existing seasonal IAV vaccine with a virus like particl ...
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 7

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European multicentre, randomised, phase III clinical trial of hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke (EuroHYP-1)

Start date: Feb 1, 2012, End date: Jan 31, 2017,

The consortium led by UKER and EuroHYP, the European Stroke Research Network for Hypothermia, proposes a large, multicentre clinical trial which will assess mild hypothermia as a novel treatment for ischemic stroke.Stroke is the second cause of death world-wide and the second cause of lost disability-adjusted life years in high-income countries. Stroke incidence rises exponentially with age, so it ...
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 38

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Glioma Actively Personalized Vaccine Consortium (GAPVAC)

Start date: Nov 1, 2012, End date: Jan 31, 2017,

"Glioblastoma (GBM) is a rare (2-3 incidences in 100,000) and fatal disease. Each year, approximately 13,000 new cases of GBM are diagnosed in Europe. The 5-year survival rate of this highly aggressive tumor entity under conventional therapy is less than 6%. Currently available therapeutic options neglect the individuality of each patients’ disease and only temporarily influence tumor progression ...
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 13

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European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR)

Start date: Mar 1, 2012, End date: Jun 30, 2016,

...trial using eye drops for treatment of the early stages of DR. The participants are top leaders in their field and central readings will be performed by the Coordinating Centre of the European Vision Institute Clinical Research Network (EVICR.Net).The main objectives of the project are the following:Primary objective: To assess whether the selected neuroprotective drugs (brimonidine and somatostat ...
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 18

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Addictions and Lifestyles In Contemporary Europe – Reframing Addictions Project (ALICE RAP)

Start date: Apr 1, 2011, End date: Mar 31, 2016,

ALICE RAP is a Europe wide project of 43 partner research institutions involving 107 researchers from 25 European countries providing 1000 months of a plurality of scientific endeavour to analyse the place and challenges of addictions and lifestyles to the cohesion, organization and functioning of contemporary European society. Through integrated multidisciplinary research, a wide range of factors ...
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 46

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International Human Microbiome Standards (IHMS)

Start date: Feb 1, 2011, End date: Jan 31, 2015,

A detailed understanding of human biology will require characterisation of the human-associated microorganisms, the human microbiome, and of the roles these microbes play in health and disease. Large projects in Europe, the United States, China and Canada target these objectives, using high throughput –omics approaches. Given the complexity of our microbial communities, composed of thousands of ...
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 8

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Pathways common to brain development and ageing: defining strategies for preventive therapy and diagnostics (DEVELAGE)

Start date: Jan 1, 2012, End date: Dec 31, 2014,

"The increasing number of elderly people will have a major impact on the prevalence of age-related diseases, which will pose major challenges to keep health systems in Europe sustainable. Current knowledge is insufficient to identify the transition of normal brain ageing into Alzheimer`s Disease (AD)-like brain damage. Elucidation of the genes and pathways contributing to the earliest stages of AD ...
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 9

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Inflammatory Bowel Disease: an EU-NZ integrated approach for characterizing its molecular multifactorial mechanisms (REINFORCE)

Start date: Jan 1, 2012, End date: Dec 31, 2014,

"Over the past 20 years there has been a dramatic rise in the incidence of Inflammatory bowel disease (IBD), both in EU and NZ. IBD refers primarily to two major disorders such as ulcerative colitis (UC) and Crohn's disease (CD), chronic conditions characterized by inflammatory lesions involving gut mucosa. CD is also an emerging problem amongst children. Etiology of IBD is still unknown, however ...
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 5

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Systems biology towards novel chronic kidney disease diagnosis and treatment (SysKID)

Start date: Jan 1, 2010, End date: Dec 31, 2014,

Chronic kidney disease (CKD) affects up to 10% of the population. Besides eventual progression towards end stage renal disease CKD impacts the patient’s quality of life by causing serious comorbidities including cardiovascular complications and bone metabolism disorders. On the everyday clinical level early stage diagnosis and tailored treatment of CKD are still inadequate. In addition, CKD seems ...
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 30

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Development of OPN-305 as an orphan drug for the treatment of Delayed Graft Function post solid organ transplantation (MABSOT)

Start date: Dec 1, 2010, End date: Sep 30, 2014,

Delayed graft function (DGF) is defined as the need for dialysis within seven days of renal transplantation (DGF promotes allograft rejection, requires prolonged dialysis and hospitalisation, and increases the likelihood of graft failure and ultimately the duration of renal graft survival-expectancy. The incidence of DGF occurs in 21-44% of cases following cadaveric renal graft. Several rare dise ...
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 10

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European Clearing House for Open Robotics Development (ECHORD)

Start date: Jan 1, 2009, End date: Dec 31, 2013,

...ORD is to provide new opportunities for coordinated and target-oriented scientific research as well as knowledge transfer in robotics and to create a productive collaboration environment for research institutions and robot manufacturers across Europe. This cooperation will reduce the fragmentation of our robotics industry. European robotics industry will be helped to achieve a significant cutting- ...
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 105

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European Stroke Research Network (EUSTROKE)

Start date: Mar 1, 2008, End date: Aug 31, 2013,

The European Stroke Research Network (EUSTROKE) will be a collaborative effort that brings together researchers, government, industry, the non-profit sector and patient group associations. This network will put Europe at the forefront of stroke research through its multi-disciplinary research program, high-quality training for European scientists and clinicians, and national and global partnership ...
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 17

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Learning from International Networks about Errors and Understanding Safety in Primary Care (LINNEAUS EURO -PC)

Start date: Mar 1, 2009, End date: May 31, 2013,

There is a deficit in activity related to patient safety in primary care and the primary care/secondary care interface in Europe. This deficit relates to research, to sharing of information, to learning and to collaboration.This co-ordination action will specifically address issues addressed in the call through: (1)The development of a taxonomy of adverse events and errors. (2) Identifying best cl ...
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 12

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Evaluation of Integrated Cardiac Imaging for the Detection and Characterization of Ischemic Heart Disease (EVINCI-study)

Start date: Jan 1, 2009, End date: Jun 30, 2012,

The main purpose of the EVINCI-study is to test the impact of combined “anatomo-functional” non invasive cardiac imaging for detection and characterization of Ischemic Heart Disease (IHD). The EVINCI-study is a prospective clinical European multicenter trial performed in a cohort of 700 patients with suspected IHD. Patients with intermediate pre-test probability will undergo clinical and biohumora ...
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 22

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Metagenomics of the Human Intestinal Tract (MetaHIT)

Start date: Jan 1, 2008, End date: Jun 30, 2012,

A detailed understanding of human biology will require not only knowledge of the human genome but also of the human metagenome, defined here as the ensemble of the genomes of human-associated microorganisms. Our proposal focuses on the microorganisms of the gut, which are particularly abundant and complex and have an important role for human health and well-being. We shall implement and integrate ...
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 16

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iNTER Support Action (International Network of Teleconsultation Excellence & Referral) (iSA)

Start date: Sep 1, 2009, End date: Feb 29, 2012,

The iNTER Support Action (iSA) Project aims to create a pilot cooperative medical support network constituted by the Hospital Son Espases (former Son Dureta) (Spain), the Instituto Valenciano de Oncología (Spain), the Hospital Vall d’Hebron (Spain), the Hospital Sant Joan de Déu (Spain), the Hospital Regional de Bata (Equatorial Guinea), the Desarrollo 2000 en África NGO (Equatorial Guinea), the H ...
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 11

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Advanced Arterial Hypotension Adverse Event prediction through a Novel Bayesian Neural Network (AVERT-IT)

Start date: Jan 1, 2008, End date: Jul 31, 2011,

Hypotension (sub-normal blood pressure) adverse events (AE's) occur commonly in patients managed in intensive care and high dependency units. Health care technology which could reduce the burden of these events by as little as ten percent would equate to at least five billion Euros p.a. saved by European healthcare organisations for use in other treatment regimensThe AVERT-IT project will create ...
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 10