The iNTER Support Action (iSA) Project aims to create a pilot cooperative medical support network constituted by the Hospital Son Espases (former Son Dureta) (Spain), the Instituto Valenciano de Oncología (Spain), the Hospital Vall d’Hebron (Spain), the Hospital Sant Joan de Déu (Spain), the Hospital Regional de Bata (Equatorial Guinea), the Desarrollo 2000 en África NGO (Equatorial Guinea), the Hospital Regional de Trujillo (Peru), the Instituto Nacional de Cancerología (Mexico), the St. John of God Hospital (Sierra Leone), CMF International, and the College of Health Sciences of the University of Nairobi in cooperation with the Kenyatta National Hospital (Kenya). The 30-month initiative, coordinated by Son Dureta, seeks to provide Web-based diagnostic and/or therapeutic support for complex medical cases requiring specialized opinions in different health areas (initially adults and pediatrics Oncology as well as Infectious Diseases). The communication among doctors and the sharing of medical cases will be performed by using a cost-efficient Web 2.0 portal that will facilitate the exchange of medical images, videos and reports. Strategic objectives of the project include the facilitation of communication and medical knowledge exchange to develop diagnostic, therapeutic and technological support actions within distinct healthcare settings, the encouragement of human resource, technology, and infrastructure investment policies, the implementation of multinational online Continuing Medical Education (CME) programs, the creation of clinical research groups, and the evaluation of an inexpensive Web platform for clinical case sharing.