Search for European Projects

19 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Penumbral Rescue by Normobaric O=O Administration in Patients With Ischaemic Stroke and Target Mismatch ProFile: A Phase II Proof-of-Concept Trial (PROOF)

Start date: Jan 1, 2017, End date: Dec 31, 2021,

Ischemic stroke (IS), caused by occlusion of arteries that supply blood to the brain, remains a leading cause of mortality and morbidity in the world. Disruption of blood and oxygen supply to the brain leads to neuronal death in the ischemic core within minutes. The hypoperfused tissue surrounding the ischemic core, the penumbra, is at high risk for infarction over time but still salvageable. Neur ...
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 13

 FINISHED 

Towards Early Molecular Diagnostics of Schizophrenia (SZ_TEST)

Start date: Jan 1, 2017, End date: Dec 31, 2020,

Schizophrenia (SZ) is a severe mental disorder affecting more than 0.7% of the adult population. One of the most disabling and emotionally devastating illnesses known to man, SZ is also associated with considerable socioeconomic burden. In general, the chronic nature and the high degree of patient disability make SZ the fourth leading cause of disease burden across the globe with the management co ...
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 9

 FINISHED 

Paediatric Clinical Research Infrastructure Network (PedCRIN)

Start date: Jan 1, 2017, End date: Dec 31, 2020,

Children’s health is a major societal challenge for Europe and the world, requiring development of paediatric medicines and treatments strategies based on evidence derived from clinical trials demonstrating efficacy and safety in infants and children, rather than on uncritical extrapolation from adult data (over 50 % of the medicines used for children had not been tested in this specific age group ...
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 16

 FINISHED 

Effect of ALlopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome (ALBINO)

Start date: Jan 1, 2016, End date: Dec 31, 2020,

Neonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of death or long-term disability in infants born at term in the western world, affecting about 1-4 per 1.000 life births and consequently about 5-20.000 infants per year in Europe.Hypothermic treatment became the only established therapy to improve outcome after perinatal hypoxic-ischemic insults. Despite hypothermia and neonatal inte ...
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 18

 FINISHED 

Clinical study in Parkinson's disease with two unique goals: 1) Proof-of-concept of CDNF protein for disease modification; 2) Validation of clinically tested device for intracerebral drug delivery (TreatER)

Start date: Jan 1, 2017, End date: Dec 31, 2019,

The main focus of TreatER is conducting a randomized, placebo-controlled, first-in-human, proof-of-concept, safety and efficacy study of intracerebrally administered CDNF protein therapy in patients with Parkinson’s disease (PD), using a neurosurgically implanted Drug Delivery System (DDS), which will also be clinically validated in the study. Thus the TreatER project has two independent goals, ei ...
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 12

 FINISHED 

Breaking the Nonuniqueness Barrier in Electromagnetic Neuroimaging (BREAKBEN)

Start date: Jan 1, 2016, End date: Dec 31, 2018,

By combining accurate magnetic measurements of neural activity with near-simultaneous high-definition measurements of cerebral structure – provided by novel methods in ultra-low-field magnetic resonance imaging (ULF MRI ) – we will be able to image the dynamics of human brain function at unprecedented resolution and reliability. BREAKBEN will achieve a revolution in neuroimaging; we aim at breakin ...
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 7

 FINISHED 

Neuropathic pain: biomarkers and druggable targets within the endogenous analgesia system (NEUROPAIN)

Start date: Jan 1, 2014, End date: Dec 31, 2018,

Neuropathic pain has a high incidence in Europe and often affects the patient’s emotional balance and quality of life. Recent meta-analyses have shown that conventional analgesic drugs are not sufficiently effective in these patients and are limited by serious side effects. The search for new analgesics is extremely difficult despite identification of several new potential targets and enormous inv ...
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 12

 FINISHED 

Global Research in Paediatrics (GRiP)

Start date: Jan 1, 2011, End date: Jun 30, 2017,

Paediatric drugs (PD) lack appropriate testing. Most drugs have inadequate information about dosing regimen, dose adjustment and how to administer them. These are longstanding problems that unquestionably require concerted efforts at the international level. Both the US and the EU have introduced paediatric legislation that facilitates participation of children in research and pharmaceutical innov ...
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 24

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Vitamin D And LIfestyle Intervention for Gestational Diabetes Mellitus (GDM) Prevention (DALI)

Start date: Mar 1, 2010, End date: Dec 31, 2015,

Europe is facing a rapidly growing threat from Type 2 diabetes mellitus (T2D), which is undoubtedly associated with an unhealthy diet and a more sedentary lifestyle. Evidence is accumulating that gestational diabetes mellitus (GDM) may be playing a role in this process. Thus it provides a significant opportunity for preventing future T2D. Not only is GDM prevalence on the rise, but intrauterine ex ...
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 18

 FINISHED 

Adopting Hospital Based Health Technology Assessment in EU (AdHopHTA)

Start date: Sep 1, 2012, End date: Nov 30, 2015,

The use of HTA as a part of the decision-making process at national, regional, and international levels has evolved considerably over the past 35 years. However, still an important number of good-value innovative HTs never reach clinical practice while, in many instances, others with no significant added value actually do. This situation can be effectively overcome by approaching HTA at hospital l ...
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 11

 FINISHED 

Mechanisms of the Development of ALLergy (MEDALL)

Start date: Dec 1, 2010, End date: May 31, 2015,

Causes explaining the epidemic of IgE-associated (allergic) diseases are unclear. MeDALL (Mechanisms of the Development of Allergy) aims at generating novel knowledge on mechanisms of allergy initiation, in particular in childhood. To understand how a complex network of genetic and environmental factors leads to complex allergic phenotypes, a novel stepwise, large and integrative translational app ...
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 24

 FINISHED 

Treatment of NEonatal seizures with Medication Off-patent: evaluation of efficacy and safety of bumetanide (NEMO)

Start date: Oct 1, 2009, End date: Mar 31, 2015,

Neonatal hypoxic ischaemic encephalopathy (HIE) occurs in 2-3/1000 live births and is a major cause of both acute mortality and long-term neurodisability. Seizures are the hallmark of HIE. The clinical and electrographic seizure burden in babies with HIE can be considerable and is often not reduced by current antiepileptic drugs. Phenobarbitone remains the first line drug for neonatal seizures des ...
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 15

 FINISHED 

Brain Diagnostics and Monitoring in early neonatal period (BraDiMo) (BraDiMo)

Start date: May 1, 2011, End date: Sep 1, 2014,

EU level payload from medical conditions associated with acute threat to brain in neonates (such as preterm birth or birthasphyxia) rises upto billions of euros each year. Yet the means to protect or monitor brains in neonatal intensive care units are far from optimal, and every improvement to this practice is likely to yield very high returns. The aim of this proposal is to fund development of re ...
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 1

 FINISHED 

Innovative functional foods based on sweet lupin protein for cardiovascular prevention (LUPICARP)

Start date: Oct 1, 2011, End date: Mar 31, 2014,

The objective is to assess the health benefits on dislipidemia prevention of innovative food products based on lupin proteins, starting from some preliminary results provided by 2 past European collaborative projects (Healthy-Profood & Bioprofibre). The core RTD activity is the implementation of a multicenter randomized dietary intervention study with LDL-cholesterol as main end-point aimed to com ...
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 12

 FINISHED 

Pathogenesis of Type 1 Diabetes - Testing the Hygiene Hypothesis (DIABIMMUNE)

Start date: Mar 1, 2008, End date: Feb 28, 2014,

"Preliminary data indicate that there is a strong association between the incidence of immune-mediated diseases and improving standard of living and hygiene. One of the steepest gradient in standard of living worldwide is present at the border between Russian Karelia and Finland with a sevenfold difference in the gross national product, while Estonia represents a country in rapid transition. These ...
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 12

 FINISHED 

Collaborative Oncological Gene-environment Study (COGS)

Start date: May 1, 2009, End date: Jan 31, 2014,

The overarching goal of COGS is to identify individuals with an increased risk of breast, ovary and prostate cancer. Furthermore, we will evaluate the effect of inherited genetic variation on tumour characteristics and clinical outcome. We will do this through quantifying the role of genetic and environmental/lifestyle risk in the largest data set ever generated. In all, we will include over 200,0 ...
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 16

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No Pain during infancy by adapting off-patent medicines (NeoOpioid)

Start date: Oct 1, 2008, End date: Sep 30, 2013,

Preterm and newborn infant may suffer from pain in the same way as adults. They are even more sensitive to pain due to immaturity of endogenous modulation. Thus, they should have the same human right to be alleviated from pain. The overall aim of this project is to assess effects and safety of opioid treatment in very preterm up to full term newborn infants in relation to pharmacokinetics predisp ...
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 13

 FINISHED 

European Stroke Research Network (EUSTROKE)

Start date: Mar 1, 2008, End date: Aug 31, 2013,

The European Stroke Research Network (EUSTROKE) will be a collaborative effort that brings together researchers, government, industry, the non-profit sector and patient group associations. This network will put Europe at the forefront of stroke research through its multi-disciplinary research program, high-quality training for European scientists and clinicians, and national and global partnership ...
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 17

 FINISHED 

Hybrid MEG-MRI Imaging System (MEGMRI)

Start date: May 1, 2008, End date: Apr 30, 2012,

"We will develop and validate hybrid magnetoencephalography (MEG) and magnetic resonance imaging (MRI) technology that will allow simultaneous structural (MRI) and functional (MEG) imaging of the human brain. MEG is a non-invasive 3D functional imaging with a high temporal resolution compared to other functional imaging but often suffers from a precise structural localization which will be solved ...
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 13