The objective is to assess the health benefits on dislipidemia prevention of innovative food products based on lupin proteins, starting from some preliminary results provided by 2 past European collaborative projects (Healthy-Profood & Bioprofibre). The core RTD activity is the implementation of a multicenter randomized dietary intervention study with LDL-cholesterol as main end-point aimed to compare the hypolipidemic effect of lupin proteins vs. animal proteins. Besides LDL-Cholesterol other inflammatory and metabolic markers will be investigated. In addition the metabolism of cholesterol will be analysed. All these data will be exploited at the end of the project by the submission of an application to the European Commission for the approval a health claim on lupin and cholesterol reduction. The project will include also product development and optimization, with particular reference to the nutrition profiles of the foods. Specific activities will be dedicated to assess the quality of the lupin proteins in the food products. Innovation activities will be dedicated also to the application of a “New Concept Development” for new products, new services and new markets for enterprises. To reach these objectives the LUPICARP consortium includes 5 food producing SMEs, 1 lupin ingredient manufacturer and 5 RTD performers expert in product innovation, food processing, clinical nutrition, pharmacology. Efficient technology transfer will be ensured to improve the competitiveness of participating SMEs.