The use of HTA as a part of the decision-making process at national, regional, and international levels has evolved considerably over the past 35 years. However, still an important number of good-value innovative HTs never reach clinical practice while, in many instances, others with no significant added value actually do. This situation can be effectively overcome by approaching HTA at hospital level, notably because hospitals are the main entry level for innovative HTs.To address these challenges, the AdHopHTA project aims at strengthening the use and impact of quality HTA results in hospital settings, making available pragmatic knowledge and tools to boost adoption of hospital based HTA initiatives. The project also aims at creating an adequate ecosystem where formal coordination among existing hospital based HTA initiatives and liaison with national and regional agencies will flourish. AdHopHTA focuses on hospital based HTA, an area not previously addressed by EUnetHTA, and in need of greater attention due to the considerable volume of resources that hospitals mobilise around investments in HTs.Through the 7 work packages, AdHopHTA will achieve the following 4 strategic objectives: 1) To perform a critical analysis of current formally established hospital based HTA initiatives; 2) To provide with a set of principles for best practice in hospital based HTA; 3) To advance a framework for setting a collaboration among current hospital based HTA initiatives and deployment to other interested EU hospitals; and, 4) To promote the collaboration and coordination of hospital HTA initiatives with HTA National/Regional organisations. The final results of AdhoptHTA will be: a) development of guiding principles on best practices for hospital based HTA; b) an accompanying toolkit to facilitate the deployment of such principles; c) the design and set-up of a database for hospital based HTA products in coordination/compatibility with the POP database (EUnetHTA)