Search for European Projects

Over 40 European Projects Found

Searched on 125080 European Projects

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Paraplegia Prevention in Aortic Aneurysm Repair by Thoracoabdominal Staging with ‘Minimally-Invasive Segmental Artery Coil-Embolization’: A Randomized Controlled Multicentre Trial (PAPA-ARTIS)

Start date: Jan 1, 2017, End date: Dec 31, 2021,

Chronic aortic aneurysms are permanent and localized dilations of the aorta that remain asymptomatic for long periods of time but continue to increase in diameter before they eventually rupture. Left untreated, the patients’ prognosis is dismal, since the internal bleeding of the rupture brings about sudden death. Although successful treatment cures the disease, the risky procedures can result in ...
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 26

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From fast food to healthy diet: Addressing the dynamic molecular mechanism of sequential diet switch-induced T cell plasticity for the purpose of developing new treatments for immuno-mediated diseases (Diet-namic)

Start date: Dec 1, 2016, End date: Nov 30, 2021,

"The incidence of chronic immune-mediated inflammatory diseases is continually increasing. Chronic inflammation has been linked to intestinal carcinogenesis, which is the second leading cause of cancer-related deaths. The cause of this increase could be the unprecedented dietary abundance typical of “Western” countries. Different types of diets shape the genetic composition and metabolic activity ...
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Take control!Towards novel training regimes enhancing inhibition and impulse control in health and psychiatric disease (Self-Control)

Start date: Aug 1, 2016, End date: Jul 31, 2021,

Self-control is at the heart of human nature and enables us to resist temptations. Several clinical disorders are characterized by an inability to control oneself, e.g. addiction and other impulse-related disorders. Since these psychiatric diseases are highly debilitating and cause substantial economic costs, any means of enhancing self-control is of high value for society at large. To date the vi ...
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Cellular substrate of abnormal network maturation in neuropsychiatric disorders (PSYCHOCELL)

Start date: Jun 1, 2016, End date: May 31, 2021,

The long-lasting burden of major neuropsychiatric disorders results from disruption of cognitive performance in daily life. Impairment of long-range coupling between prefrontal cortex and hippocampus represents the substrate of disease-specific mnemonic and executive deficits. While it has been hypothesized that this impairment emerges long before the first clinical symptoms, technical and ethical ...
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European HIV Vaccine Alliance (EHVA): a EU platform for the discovery and evaluation of novel prophylactic and therapeutic vaccine candidates (EHVA)

Start date: Jan 1, 2016, End date: Dec 31, 2020,

Many HIV vaccine concepts and several efficacy trials have been conducted in the prophylactic and therapeutic fields with limited success. There is an urgent need to develop better vaccines and tools predictive of immunogenicity and of correlates of protection at early stage of vaccine development to mitigate the risks of failure. To address these complex and challenging scientific issues, the Eur ...
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Novel multimodal approach to atrial fibrillation risk assessment and identification of targets for prevention by interdisciplinary exploitation of omics, advanced electrocardiography, and imaging (MMAF)

Start date: Jan 1, 2016, End date: Dec 31, 2020,

There is a growing need for novel risk schemes in atrial fibrillation (AF) to permit prevention, contribute to a better understanding of the pathophysiology, and discover targets for individualized treatment.Primary prevention efforts are scant despite the imminent AF epidemic. In international cohorts I have developed and validated the first risk prediction algorithm. However, it explains only 60 ...
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PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke (PRECIOUS)

Start date: Jun 1, 2015, End date: May 31, 2020,

Every year, 1.3 million Europeans have a stroke and one million ultimately die of stroke. One third of stroke patients remain dependent on the help of others. The annual costs for stroke care in Europe are estimated at € 64.1 billion. Stroke incidence increases almost exponentially with age, and the personal, societal, and economic burden of stroke is therefore largely driven by its frequent occur ...
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Cancer treatment and monitoring through identification of circulating tumour cells and tumour related nucleic acids in blood (CANCER-ID)

Start date: Jan 1, 2015, End date: Dec 31, 2019,

Blood-based biomarkers such as Circulating Tumor Cells (CTCs), circulating free tumor DNA (cfDNA) and microRNAs (miRNAs) have the potential to improve the development of personalized medicines for cancer patients. This is of particular importance when biopsies of the primary tumor or metastases are not accessible (e.g. at early disease stages or in minimal residual disease) or possible and the ass ...
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EU Training Network on Novel Targets and Methods in Atrial Fibrillation (AFib-TrainNet)

Start date: Sep 1, 2015, End date: Aug 31, 2019,

The AFib-TrainNet consortium will enable promising young scientists to become excellent research leaders of the future, capable of fighting the challenges that Atrial Fibrillation (AF) presents to the European population. AF is the most common sustained cardiac arrhythmia, occurring in between 1-2% of the general population. More than 6 million Europeans suffer from this arrhythmia and its prevale ...
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 7

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Individualized early risk assessment for heart diseases (IndivuHeart)

Start date: Jun 1, 2014, End date: May 31, 2019,

Heart failure (HF) is the common end-stage of different medical conditions. It is the only growing cardiovascular disease and its prognosis remains worse than that of many malignancies. The lack of evidence-based treatment for patients with diastolic HF (HFpEF) exemplifies that the current “one for all” therapy has to be advanced by an individualized approach. Inherited cardiomyopathies can serve ...
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A drug strategy targeting stabilised mutant p53 to fight metastatic platinum-resistant ovarian cancer (GANNET53)

Start date: Oct 1, 2013, End date: Mar 31, 2019,

"Epithelial ovarian cancer (EOC) is the most lethal gyncaecological malignancy causing 41900 deaths annually in Europe. The predominance of aggressive Type II tumours, which are characterised by a high frequency of p53 mutations, and primary or acquired resistance to platinum-based chemotherapy profoundly contribute to the high mortality rate. With current standard therapy the median overall survi ...
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Mechanisms of social attention (MESA)

Start date: Feb 1, 2014, End date: Jan 31, 2019,

"A fundamental research question of several disciplines concerns the description, explanation and prediction of human behavior in social contexts. While significant research had been devoted to higher order social capabilities, much less is known about basic principles that are underlying these functions. This is especially true for social attention which is at the heart of every higher order soci ...
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Does vascular endothelial growth factor gene therapy safely improve outcome in severe early-onset fetal growth restriction? (EVERREST)

Start date: Jan 1, 2013, End date: Dec 31, 2018,

Fetal growth restriction (FGR) globally occurs in 8% of pregnancies, is severe and early onset in 1:500 cases, affecting 11,000 babies annually in the EU. In most cases, reduced uterine blood flow restricts substrate delivery to the fetus causing growth to slow or cease. There is no treatment. Currently the fetus is delivered very preterm before fetal death or irreversible organ damage occurs. Aff ...
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How the human brain combines the certainty of prior expectations and the clarity of sensory input during speech perception (EXPECTBRAIN)

Start date: Jan 1, 2017, End date: Dec 31, 2018,

A fundamental question in the study of human perception concerns how we combine new sensory information with prior knowledge. Different underlying neural mechanisms have been proposed for how perceptual priors are combined with sensory input depending on their respective certainty to generate a subjective experience. Predictive Coding models suggest that neuronal populations compare (bottom-up) in ...
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Socialising Sensori-Motor Contingencies (socSMCs)

Start date: Jan 1, 2015, End date: Dec 31, 2018,

As robots become more omnipresent in our society, we are facing the challenge of making them more socially competent. However, in order to safely and meaningfully cooperate with humans, robots must be able to interact in ways that humans find intuitive and understandable. Addressing this challenge, we propose a novel approach for understanding and modelling social behaviour and implementing social ...
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Identifying the immune and microbial network controlling the IL-22 – IL-22bp axis to open the doors for targeted therapies (IL-22 and IL-22BP)

Start date: Jan 1, 2014, End date: Dec 31, 2018,

Chronic mucosal inflammation and tissue damage predisposes patients to the development of colorectal cancer. One hypothesis is that the same factors important for wound healing, if left unchecked, also promote tumorigenesis. Tight control by a sensor of tissue damage should induce these factors to promote tissue repair, while limiting their activity to prevent development of cancer.IL-22, a protot ...
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 2

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Developing new therapies for Batten disease (BATCure)

Start date: Jan 1, 2016, End date: Dec 31, 2018,

The goal of BATCure is to advance the development of new therapeutic options for a group of rare lysosomal diseases - neuronal ceroid lipofuscinoses (NCL) or Batten disease. There are > thousand affected across Europe, with a combined incidence of c.1:100 000. The NCLs are devastating and debilitating genetic disorders that mainly affect children, who suffer progressive dementia and motor decline, ...
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 14

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The polyphosphate/factor-XII pathway in cancer-driven thrombosis and tumor growth (PolyP-FXII in cancer)

Start date: Jan 1, 2017, End date: Dec 31, 2018,

Cancer is a leading cause of venous thrombosis. Tumor-driven procoagulant mechanisms and therapies for interference with cancer-associated thrombosis are poorly developed and are associated with life-threatening bleeding complications. Coagulation factor XII is a protease that is essential for thrombus formation while being dispensable for hemostatic processes that terminate blood loss. Challengin ...
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Systems biology for the functional validation of genetic determinants of skeletal diseases (SYBIL)

Start date: Oct 1, 2013, End date: Sep 30, 2018,

"The aim of SYBIL is to carry out extensive functional validation of the genetic determinants of rare and common skeletal diseases and the age related factors contributing to these painful conditions. To achieve this goal SYBIL will gather complementary translational and transnational scientists, systems biologists, disease modellers, leading SMEs and industrialists that will perform in-depth char ...
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Human Brain Project Specific Grant Agreement 1 (HBP SGA1)

Start date: Apr 1, 2016, End date: Mar 31, 2018,

Understanding the human brain is one of the greatest scientific challenges of our time. Such an understanding can provide profound insights into our humanity, leading to fundamentally new computing technologies, and transforming the diagnosis and treatment of brain disorders. Modern ICT brings this prospect within reach. The HBP Flagship Initiative (HBP) thus proposes a unique strategy that uses I ...
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CaMKII over stimulation in engineered heart tissues (EHTs) made from human induced pluripotent stem cells (hiPSCs): a parameter involved in the immaturity of hiPSC EHTs cardiomyocytes? (EHT-CaMKII)

Start date: Apr 1, 2016, End date: Mar 31, 2018,

In Europe, as observed in other parts of the world, cardiovascular (CV) diseases represent the leading cause of death. In the European Union, CV deaths account for 1.9 million deaths per year, and treatment costs for CV disease amount to an estimated 200 billion Euros per year. CV diseases encompass various pathologies that can lead to a progressive loss of cardiac contractile function and the cli ...
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Cortical Dynamics of Decision Irrationality (CODIR)

Start date: Apr 1, 2016, End date: Mar 31, 2018,

Imagine that you choose a large house with a long commute over a small flat with a short train ride. Will the appearance of an inferior, thus irrelevant, alternative–a small flat with a longer train ride–make you revise your initial choice? Contrary to what theories in economics prescribe people typically reverse their original choice in the presence of an inferior option. Contextual preference re ...
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A systems biology approach to RESOLVE the molecular pathology of two hallmarks of patients with metabolic syndrome and its co-morbidities; hypertriglyceridemia and low HDL-cholesterol (RESOLVE)

Start date: Jan 1, 2013, End date: Dec 31, 2017,

"Through combining basic pre-clinical and clinical research, network analysis and computational modelling, RESOLVE aims at resolving the disturbed dynamics and mechanisms underlying the high triglyceride (HTG) and low high-density lipoprotein cholesterol (HDL-C) phenotype and insulin resistance in patients with metabolic syndrome (MetS) and its associated co-morbidities (cardiovascular disease, CV ...
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 14

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Efficacy and safety of MRI-based thrombolysis in wake-up stroke: a randomised, double-blind, placebo-controlled trial (WAKE-UP)

Start date: Dec 1, 2011, End date: Nov 30, 2017,

WAKE-UP is an investigator-initiated, multicentre, randomised, double-blind, placebo-controlled trial designed to test efficacy and safety of MRI-based intravenous thrombolysis in patients with wake-up stroke. Every year 1.5 million patients suffer a stroke in the EU. Up to 20% of stroke patients wake up with stroke symptoms. Currently these patients are excluded from thrombolysis which is the onl ...
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 13

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Picosecond Infrared Laser for Scarfree Surgery with Preservation of the Tissue Structure and Recognition of Tissue Type and Boundaries (SUREPIRL)

Start date: Dec 1, 2012, End date: Nov 30, 2017,

"The proposed research is based on a recent breakthrough in directly observing atomic motions during structural changes and in studying energy redistribution channels in liquid water on the femtosecond time scale. These studies provided the key insights that drove the development of a new laser concept for direct-drive laser ablation. By judicious choice of laser pulse parameters, it is now possib ...
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 3

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Mesoscopic characterization of human white-matter: a computational in-vivo MRI framework (MWMI)

Start date: Dec 1, 2015, End date: Nov 30, 2017,

The goal of this highly multi-disciplinary and inter-sectional proposal is to develop a novel computational in-vivo MRI technique, namely Mesoscopic White-Matter magnetic resonance Imaging (MWMI). MWMI will measure 5 specific micro-scale metrics at a mesoscopic spatial resolution of about 300 μm: myelin, iron, water concentration, axonal density, and the ratio between inner and outer fiber diamete ...
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Personalized minimization of immunosuppression after solid organ transplantation by biomarker-driven stratification of patients to improve long-term outcome and health-economic data of transplantation (BIO-DrIM)

Start date: Nov 1, 2012, End date: Oct 31, 2017,

Organ transplantation has emerged as the “gold standard” therapy for end-stage organ failure. Incomplete control of chronic allograft injury but also the adverse effects of long-term immunosuppression (IS) continue to challenge the long-term success of transplantation. The paradigm is shifting from increasing “net”-IS by novel drugs to the concept of minimizing long-term IS as early as possible. H ...
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Chronotherapeutic lifestyle intervention for diabetes and obesity to reset the circadian rhythm and improve cardiometabolic risk in the European working population (EURHYTHDIA)

Start date: Oct 1, 2011, End date: Jun 30, 2017,

Modern lifestyle has dramatically changed the daily rhythms of life. Physical activity, diet and light exposure are no longer restricted to daytime hours, as technical and economical de-mands fuel the necessity to work outside usual working hours. Recent studies show that al-tered light exposure, shifted exercise patterns and untimely food intake following extended active periods into the night di ...
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European Multicentre Tics in Children Studies (EMTICS)

Start date: Dec 1, 2011, End date: May 31, 2017,

This project will undertake pre-clinical and cohort studies that address susceptibility factors for paediatric and adolescent tic disorders, with a particular focus on comorbid obsessive-compulsive symptomatology, from clinical, epidemiological, genetic, microbiological and immunological angles. EMTICS aims to elucidate the complex aetiology of the onset and clinical course of chronic tic disorder ...
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Investigating Ror2-dependent non-canonical Wnt signaling in bone remodeling (ROR2BONE)

Start date: May 1, 2015, End date: Apr 30, 2017,

Wnt signaling is composed of the canonical and non-canonical pathways. Canonical Wnt signaling is dependent on β-catenin activation and has become a major focus for targeting osteoblast-mediated bone formation in the context of treating the debilitating disease osteoporosis. However, much less is known about the role of the non-canonical pathway in bone formation. Unpublished data of the host labo ...
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Mechanisms and Treatment of Migraine and its Chronification (EUROHEADPAIN)

Start date: Feb 1, 2014, End date: Jan 31, 2017,

Migraine is a common brain disorder, typically characterised by recurring, incapacitating attacks of 1-3 days of severe headache, autonomic dysfunction, and sometimes aura symptoms. The disease affects 15% of all European citizens including children, ranks among the WHO top 12 of most disabling and undertreated disorders, and is responsible for the highest socio-economic burden of any brain ailmen ...
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Rational Bioactive Materials Design for Tissue Regeneration (BIODESIGN)

Start date: Jan 1, 2012, End date: Dec 31, 2016,

The development of functional materials for tissue regeneration is today mostly based on perceived and limited design criteria often using a single point approach with lengthy animal trials. The outcome after in-vitro and in-vivo evaluation is often disappointing resulting in a tedious iteration process. The main objective of this project is to achieve radical innovations in state-of-the-art bioma ...
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A Streptavidin Microarray Platform for Capturing of Circulating Tumor Cells from the Blood of Cancer Patients (CAPTURE-CTC)

Start date: Jun 1, 2015, End date: Nov 30, 2016,

The main cause of death in cancer patients is not the primary tumor but rather metastasis, which is initiated by the spread of circulating tumor cells (CTCs) in the blood. Therefore, CTCs will become a valuable diagnostic tool, once a reliable, cost-effective method is established. Research in the ongoing ERC Advanced Investigator Grant DISSECT (PI: Klaus Pantel) has revealed clear limitations of ...
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The Human Brain Project (HBP)

Start date: Oct 1, 2013, End date: Sep 30, 2016,

Understanding the human brain is one of the greatest challenges facing 21st century science. If we can rise to the challenge, we can gain profound insights into what makes us human, develop new treatments for brain diseases and build revolutionary new computing technologies. Today, for the first time, modern ICT has brought these goals within sight. The goal of the Human Brain Project, part of the ...
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The placebo effect – a window into the relationship between mind and body (PLACEBO)

Start date: Sep 1, 2011, End date: Aug 31, 2016,

"Recent data suggest the placebo effect to be a powerful demonstration of how mental activity that is shaped by expectation and experience can influence physiological functions. The current strategy to minimize potential placebo effects largely ignores the positive effects of the placebo response. The current proposal postulates a radically different approach: Instead of considering placebo effect ...
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Uncovering the mechanism and physiological relevance of myosin-VI-dependent AMPA receptor trafficking in neurons (MeReMy6)

Start date: Aug 1, 2012, End date: Jul 31, 2016,

The proper trafficking of membranes and associated proteins in neurons is crucial for the function of the nervous system. Myosin-VI is an actin-based cytoskeletal motor that promotes membrane trafficking and is suggested to play crucial roles in neurons. Most notably, the myosin affects the intracellular trafficking of AMPA receptors, major neurotransmitter receptors composed of transmembrane prot ...
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The merging of the senses: understanding multisensory experience (MULTISENSE)

Start date: Aug 1, 2011, End date: Jul 31, 2016,

"The integration of information across different sensory channels is a fundamental problem that we have to solve in every moment of daily life. We will study four key aspects of multisensory processing that are currently unresolved: (1) the role of dynamic binding in multisensory experience; (2) the role of action and sensorimotor contingencies in multisensory processing; (3) the modulation of mul ...
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Disseminating tumor cells as novel biomarkers: Dissecting the metastatic cascade in cancer patients (DISSECT)

Start date: Aug 1, 2011, End date: Jul 31, 2016,

"Breast, prostate, lung and colorectal cancer as solid tumours derived from epithelial tissues are responsible for 90% of all new cancers in Europe. Present tumour staging is mainly based on local tumour extension, metastatic lymph node involvement and evidence of overt distant metastasis obtained by imaging technologies. However, these staging procedures are not sensitive enough to detect early t ...
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Beratung in der Pflegepraxis

Start date: Jun 1, 2015, End date: May 31, 2016,

The school of Nursing Stolzalpe has organized successfully in EU- mobility projects since 2003. Our students should gain many competences through the theoretical as well as through the practical lessons. The aim of the nursing school Stolzalpe is to prepare the students at the best possible rate for the numerous challenges in the field of nursing and for lifelong learning. By taking place in EU mo ...
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Degradation of Neutrophil Extracellular Traps and its impact on thrombolysis (NET-LYSIS)

Start date: Apr 1, 2014, End date: Mar 31, 2016,

Thrombosis is a major cause of morbidity and mortality emphasizing the need for new antithrombotic therapies.Recently, a novel pro-thrombotic mechanism was uncovered: Neutrophil Extracellular Traps (NETs). Neutrophils, the chief cells of the innate immunity, release DNA fibers during thrombosis. These extracellular DNA filaments form web-like structures known as NETs, which provide a scaffold a ...
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