Search for European Projects

29 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Heart OMics in AGEing (HOMAGE)

Start date: Feb 1, 2013, End date: Jan 31, 2019,

As more people survive into old age, the prevalence of heart failure (HF), one of the most common and debilitating diseases in older people, will rise still further. Delaying or preventing HF will have great benefit to those at personal risk, their families, society and the economy. HOMAGE aims to provide a biomarker (BM) approach that will a) help identify i. patients at high risk of developing ...
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 22

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Targets and biomarkers for antiepileptogenesis (EPITARGET)

Start date: Nov 1, 2013, End date: Oct 31, 2018,

Epilepsy is a devastating condition affecting over 50 million people worldwide. This multidisciplinary project is focused on the process leading to epilepsy, epileptogenesis, in adults. Our main hypothesis is that there are combinations of various causes, acting in parallel and/or in succession, that lead to epileptogenesis and development of seizures. Our central premise and vision is that a comb ...
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 20

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Framework to respond to regulatory needs of future nanomaterials and markets (FutureNanoNeeds)

Start date: Jan 1, 2014, End date: Dec 31, 2017,

Rapidly developing markets such as green construction, energy harvesting and storage, advanced materials for aerospace, electronics, medical implants and environmental remediation are potential key application targets for nanomaterials. There, nanotechnology has the potential to make qualitative improvements or indeed even to enable the technology. Impacts range from increased efficiency of energy ...
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 26

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Proteomic prediction and Renin angiotensin aldosterone system Inhibition prevention Of early diabetic nephRopathy In TYpe 2 diabetic patients with normoalbuminuria (PRIORITY)

Start date: Jan 1, 2012, End date: Dec 31, 2017,

Patients with diabetes are at risk of developing diabetic nephropathy, which will ultimately result in the requirement for renal replacement therapy and is also associated with high cardiovascular morbidity and mortality. Detection of low concentrations of albuminuria in urine (microalbuminuria) is the current clinical standard for detecting those at significant risk and targeting preventive treat ...
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 21

 FINISHED 

Stem-cell based therapy for kidney repair (STELLAR)

Start date: Nov 1, 2012, End date: Oct 31, 2017,

Chronic kidney disease (CKD) affects 8% of the European population and ultimately results in renal failure due to progressive fibrosis. CDK carries a high mortality risk and the number of affected people rises, increasing the demand on renal replacement therapies while the number of available donor organs stays stable.The STELLAR consortium proposes to develop an alternative to renal replacement ...
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 15

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MULTISCALE APPROACH TO THE IDENTIFICATION OF MOLECULAR BIOMARKERS IN ACUTE HEART FAILURE INDUCED BY SHOCK (Shockomics)

Start date: Oct 1, 2013, End date: Sep 30, 2017,

The management of cardiovascular stability in shock patients is of paramount importance in critical care. New, cutting edge knowledge is necessary to overcome the shortcomings of available therapies, in order to cope with the challenges that anesthesiologists, intensive care specialists and emergency physicians face when dealing with shock patients.Current therapies are targeted to reduce symptoms ...
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 11

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European Consortium for High-Throughput Research in Rare Kidney Diseases (EURENOMICS)

Start date: Oct 1, 2012, End date: Sep 30, 2017,

EURenOmics will integrate several established consortia devoted to rare kidney diseases with eminent need and potential for diagnostic and therapeutic progress (i.e. steroid resistant nephrotic syndrome, membranous nephropathy, tubulopathies, complement disorders such a haemolytic uraemic syndrome, and congenital kidney malformations). The Consortium has access to the largest clinical cohorts asse ...
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 29

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European multicentre, randomised, phase III clinical trial of hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke (EuroHYP-1)

Start date: Feb 1, 2012, End date: Jan 31, 2017,

The consortium led by UKER and EuroHYP, the European Stroke Research Network for Hypothermia, proposes a large, multicentre clinical trial which will assess mild hypothermia as a novel treatment for ischemic stroke.Stroke is the second cause of death world-wide and the second cause of lost disability-adjusted life years in high-income countries. Stroke incidence rises exponentially with age, so it ...
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 38

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A European multicentre double-blind placebo-controlled phase III trial of nilvadIpine in mild to moderate Alzheimer’s disease (NILVAD)

Start date: Jan 1, 2012, End date: Dec 31, 2016,

Alzheimer’s disease (AD) is an ever-increasing public health concern among the aging population and is the most common form of dementia affecting more than 15 million individuals worldwide and around 5 million Europeans. The direct and indirect costs of AD and other dementias amount to more than €440,000 million each year (www.alz.org, 2010).Even modest therapeutic advances that delay disease onse ...
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 17

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Translational research (training) in Polycystic Kidney Disease (TranCYST)

Start date: Dec 1, 2012, End date: Nov 30, 2016,

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is an inherited kidney disorder with a prevalence of more than 1:1000, characterized by the development of renal cysts, slowly progressing towards end-stage renal disease. ADPKD is often associated with extra-renal complications, which can be devastating. Current therapy is directed towards limiting the morbidity and mortality from these complic ...
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 7

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A Gateway to European Kidney Research Resources - KidneyConnect (KidneyConnect)

Start date: Aug 1, 2013, End date: Jul 31, 2016,

Diabetes, Cardiovascular and Chronic kidney (DCC) -diseases are relentlessly increasing globally, causing enormous human suffering, premature deaths and unsustainable costs. Leading European research has indisputably pointed that the kidney filtration barrier and its epithelial cell, the podocyte, is a common denominator for the DCC-diseases. However, European excellence and expertise have remaine ...
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 19

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Search for novel molecules cross-talking between muscle and cancer with therapeutic potential against cachexia and cancer (muscleandcancer)

Start date: Jun 1, 2012, End date: May 31, 2016,

Cancer cachexia is a life-threatening syndrome characterized by severe body weight loss, due to depletion of adipose tissue and skeletal muscle, and affects up to 80% of patients with advanced cancers. The rapid loss of muscle mass is the main cause of function impairment, fatigue and respiratory complications, leading to death in 20-48% of cases. To date, no effective treatment is available. By u ...
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 2

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Dreaming of no more renal dialysis: how self-derived tissue and cells can replace renal function (RESET)

Start date: May 1, 2011, End date: Apr 30, 2016,

"For chronic kidney diseases there is little chance that the vast majority of the world¿s population will have access to renal replacement therapy with dialysis. There is yet no adequate alternative with curative intent than allo-transplantation. This approach is seriously impaired by eventually limited graft survival and by the scarce availability of donors. We propose an innovative strategy that ...
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 1

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Treat Infections in NeoNates 2 - Evaluation of an infective agent (azithromycin) for the treatment of infections in preterm and term neonates (TINN2)

Start date: Jan 1, 2011, End date: Dec 31, 2015,

"The aim of TINN2 is to evaluate azithromycin, included in the EMEA priority list of the therapeutic areas that need specific drug evaluation in preterm and term neonates. Azithromycin is a macrolid antibiotic with anti-inflammatory properties active against Ureaplasma. It might be effective in reducing the severity of bronhopulmonary disease in which Ureaplasma infection and inflammation play a r ...
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 17

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Modelling properties, interactions, toxicity and environmental behaviour of engineered nanoparticles (NANOPUZZLES)

Start date: Jan 1, 2013, End date: Dec 31, 2015,

"Nanotechnology is rapidly expanding. However, some types of engineered nanoparticles can be toxic for living organisms and exhibit negative impact on the environment. Thus, the design of new nanomaterials must be supported by a rigorous risk analysis. Following the recommendations by the EU REACH system and regarding ethical aspects, the risk assessment procedures should be performed with possibl ...
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 5

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Predictive toxicology of engineered nanoparticles (PRENANOTOX)

Start date: Jan 1, 2013, End date: Dec 31, 2015,

The production of many consumer products based on manufactured NanoParticles (NPs) has led to a growing public and regulatory concern about the safety of nanomaterials. Since experimental toxicological testing of NPs, especially in vivo animal studies is costly and time-consuming, it is necessary to develop a novel research field and associated methods and tools to reach the goal of predictive nan ...
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 3

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SUrrogate markers for vascular Micro- and Macrovascular hard endpoints for Innovative diabetes Tools (SUMMIT)

Start date: Nov 1, 2009, End date: Oct 31, 2015,

Diabetes mellitus is a lifelong, incapacitating disease affecting multiple organs. Worldwide prevalence figures estimate that there will be 246 million diabetic patients in 2007 and 380 million in 2025. Presently, diabetes can neither be prevented nor cured and the disease is associated with devastating chronic complications including coronary heart disease and stroke (macrovascular disease) as we ...
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 27

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Evaluation of antibiotics (ciprofloxacin and fluconazole) for the treatment of infections in preterm and term neonates (TINN)

Start date: Nov 1, 2008, End date: Oct 31, 2015,

The aim of TINN is to evaluate ciprofloxacin, fluconazole and micafungin in neonates; two anti-infectious drugs included in the EMEA priority list of the therapeutic areas that need specific drug evaluation in preterm and term neonates. These drugs are prescribed off-label to treat neonatal infections that are life threatening situations and associated with long-term complications. In order to val ...
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 16

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THE HYGIENE HYPOTHESIS : REVISITING THE CONCEPT BY INTEGRATING EPIDEMIOLOGY AND MECHANISTIC STUDIES (HYGIENE)

Start date: Aug 1, 2010, End date: Jul 31, 2015,

The hygiene hypothesis postulating the paradoxical protective role of infections on immune-mediateddiseases including atopy (i.e. atopic dermatitis, rhinitis, asthma) and more recently autoimmune diseases hasbeen the matter of extensive investigation. The aim of the present project is to validate this hypothesisintegrating epidemiological and experimental studies.We will review in a meta-analysis ...
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 2

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Pharmacoepidemiolocal Research on Outcomes of Therapeutics by a European ConsorTium (PROTECT)

Start date: Sep 1, 2009, End date: Apr 30, 2015,

Recent pharmacovigilance (PV) issues have led to questions regarding the ability of the current PV system to meet the global needs. Controversies around the assessment of spontaneous reports and conflicting results from pharmacoepidemiology studies may lead to delay in, or inappropriate, regulatory decisions. The PROTECT consortium, consisting of 20 core partners lead by the European Medicines Age ...
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 36

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Systems biology towards novel chronic kidney disease diagnosis and treatment (SysKID)

Start date: Jan 1, 2010, End date: Dec 31, 2014,

Chronic kidney disease (CKD) affects up to 10% of the population. Besides eventual progression towards end stage renal disease CKD impacts the patient’s quality of life by causing serious comorbidities including cardiovascular complications and bone metabolism disorders. On the everyday clinical level early stage diagnosis and tailored treatment of CKD are still inadequate. In addition, CKD seems ...
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 30

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European Communication on Research Awareness Needs (ECRAN)

Start date: Sep 1, 2012, End date: Aug 31, 2014,

"The ECRAN (European Communication on Research Awareness Needs) project is designed to develop a portfolio of open educational resources, including a film, for the general population about the challenges raised by independent clinical research.The European Commission (FP7 Health Priority) decided to allocate substantial funding to independent (investigator-driven) clinical trials. Together with me ...
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 10

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Fixed Dose Combination drugs for Secondary Cardiovascular Prevention (FOCUS)

Start date: Jul 1, 2010, End date: Jun 30, 2014,

Cardiovascular diseases (CVD) are the leading cause of death worldwide, and their incidence is increasing sharply in developing countries. Two insufficiently addressed factors contribute to increased morbidity and mortality, threatening the effectiveness of any health system: poor patient adherence to treatment, and limited access to medication in resource-poor countries and regions. To address th ...
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 9

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Coordinating resources to assess and improve health status of migrants from Latin America (COHEMI)

Start date: Jan 1, 2011, End date: Dec 31, 2013,

"European health systems are committed to meeting the challenge of understanding the needs of migrant populations and adapting their services to meet these needs. The difficulties inextricably linked to this challenge are caused by the complexity of migration patterns and the differences between migrant population across EU countries. At present, the limited available data show that attempts to in ...
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 10

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Pricing Policies and Control of Tobacco in Europe (PPACTE)

Start date: Feb 1, 2009, End date: Apr 30, 2012,

"Price is the single most important intervention in tobacco control (TC). To protect the health of its citizens the EU now has a major role in regulating tobacco fiscal policy (FP) through a number of EU directives. The aims of these directives initially were to ensure the proper functioning of the internal market. The directives aided harmonization in EU Member States (MS) but now with EU enlarge ...
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 8

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Cell permeable peptides as drug delivery system: a way towards innovative therapeutic strategies for neurodegeneration (cPADS)

Start date: Mar 1, 2008, End date: Feb 29, 2012,

Peptides and small molecules able to modulate protein-protein interaction as well as intracellular pathways leading to neurodegeneration and cell death hold a great potential as innovative therapeutic strategies with which to probe and manipulate biological pathways. The need to deliver these biologically active agents into cells has encouraged to develop various transducing vectors. In this view ...
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 5

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Patient specific image-based computational modelling for \nimprovement of short- and long-term outcome of vascular access \nin patient on hemodialysis therapy (ARCH)

Start date: Jun 1, 2008, End date: Nov 30, 2011,

More than half a million people live in Europe on chronic renal replacement therapy by hemodialysis (HD). This number increases annually at a constant rate of 8%. The Achilles heel of HD is the vascular access (VA) used to connect patient circulation to the artificial kidney. The current recommendation for VA is the native arteriovenous fistula (AVF), surgically created in the forearm. VA dysfunct ...
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 10

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Set up and comparison of multiple stem cell approaches for kidney repair (STAR-T REK)

Start date: Nov 1, 2008, End date: Oct 31, 2011,

"With the increasing rate of end-stage renal failure and limited alternatives for its treatment, potential regenerative approaches for kidney damages are urgently needed. Because of the complexity of the organ, the development of stem cell therapies for kidney is still in its infancy. Identifying which cell types are capable of beneficial effects is the critical step required to realize the potent ...
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 11

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European Network of Bipolar Research Expert Centres (ENBREC)

Start date: Jul 1, 2009, End date: Jun 30, 2011,

"Bipolar (BP) disorder is characterized by recurrent manic and depressive episodes, affecting more than 1% of the EU population. Delay in the diagnosis (based only on clinical features), uncertainties in the definition of episodes and on the treatment strategy best adapted to each patient lead to devastating socio-economic, professional and family consequences that be reverted by optimized diagnos ...
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 6