Search for European Projects

14 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Restoring tissue regeneration in patients with visceral Graft versus Host Disease. (RETHRIM)

Start date: Jan 1, 2015, End date: Dec 31, 2019,

Stem cell regenerative therapies hold great promise for patients suffering from a variety of disorders that are associated with tissue or organ injury. Regeneration relies on tissue or organ-specific stem and progenitor cells, but can also aim at promoting the endogenous repair capacity of the body. Mesenchymal stromal cells (MSC) are undergoing clinical testing in a variety of clinical conditions ...
Read Project

 12

 FINISHED 

Long-term, prospective study evaluating clinical and molecular biomarkers of epileptogenesis in a genetic model of epilepsy – tuberous sclerosis complex (EPISTOP)

Start date: Nov 1, 2013, End date: Oct 31, 2018,

Despite a great progress in the management of epilepsy, still one third of patients is refractory to available medications. The incidence of epilepsy is highest in infancy and 50% of children experience epilepsy-related comorbidities, such as developmental delay and autism. The development of epilepsy (epileptogenesis), extensively studied in animals, is barely studied in humans, as patients usual ...
Read Project

 16

 FINISHED 

Health and Environment-wide Associations based on Large population Surveys (HEALS)

Start date: Oct 1, 2013, End date: Sep 30, 2018,

Assessing individual exposure to environmental stressors and predicting health outcomes implies that both environmental exposures and epi/genetic variations are reliably measured simultaneously. HEALS (Health and Environment-wide Associations based on Large population Surveys) brings together in an innovative approach a comprehensive array of novel technologies, data analysis and modeling tools th ...
Read Project

 37

 FINISHED 

Systems Biology to Identify Molecular Targets for Vascular Disease Treatment (SYSVASC)

Start date: Feb 1, 2014, End date: Jan 31, 2018,

Asymptomatic vascular damage accumulates for years before patients are identified and subjected to therapeutic measures. The limited knowledge on early vascular disease pathophysiology is reflected in the lack of therapeutic options. SysVasc aims to overcome this limitation by mounting a comprehensive systems medicine approach to elucidate pathological mechanisms, which will yield molecular target ...
Read Project

 19

 FINISHED 

Optimized esterase biocatalysts for cost-effective industrial production (OPTIBIOCAT)

Start date: Dec 1, 2013, End date: Nov 30, 2017,

"OPTIBIOCAT is a 48 months project aimed at developing biocatalysts based on feruloyl esterases (FAEs) and glucuronoyl esterases (GEs) for production of phenolic fatty- and sugar- esters with antioxidant activity for cosmetic industry, expanding the number/type of industrial biotransformations. Selected FAEs and GEs available within the consortium will be improved for their thermo- and solvent- re ...
Read Project

 16

 FINISHED 

Long-term effects of early nutrition on later health (EARLYNUTRITION)

Start date: Feb 1, 2012, End date: Oct 31, 2017,

Nutrition during early development has an important impact on later health, particularly through greater obesity risk, as demonstrated by FP6 EARNEST. EarlyNutrition explores the current key hypotheses on likely causes and pathways to prevention of early life origins of obesity (specifically adiposity) and associated disorders. We bring extraordinary expertise and study populations of 470,000 indi ...
Read Project

 40

 FINISHED 

Clinical and system –omics for the identification of the MOlecular DEterminants of established Chronic Kidney Disease (iMODE-CKD)

Start date: Sep 1, 2013, End date: Aug 31, 2017,

iMODE-CKD integrates multi-disciplinary expertise in proteomics, metabolomics, transcriptomics, bioinformatics, pathology, and clinical science from leading academic and industrial investigators, establishing a unique training platform on biomarker research and Systems Biology. Special emphasis is placed on the application of a wide range of –omics and bioinformatics techniques to clinical researc ...
Read Project

 10

 FINISHED 

Translational research (training) in Polycystic Kidney Disease (TranCYST)

Start date: Dec 1, 2012, End date: Nov 30, 2016,

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is an inherited kidney disorder with a prevalence of more than 1:1000, characterized by the development of renal cysts, slowly progressing towards end-stage renal disease. ADPKD is often associated with extra-renal complications, which can be devastating. Current therapy is directed towards limiting the morbidity and mortality from these complic ...
Read Project

 7

 FINISHED 

International study for treatment of childhood relapsed ALL 2010 with standard therapy, systematic integration of new agents, and establishment of standardized diagnostic and research (INTREALL)

Start date: Oct 1, 2011, End date: Sep 30, 2016,

Though survival of children with acute lymphoblastic leukaemia (ALL) has improved, relapse remains a leading cause of mortality in childhood cancer. Given the rarity of the disease, only a large international cooperative group can recruit sufficient patients for prospective studies with specific questions in biologic subgroups. Under the umbrella of the I-BFM SG all relevant mainly European study ...
Read Project

 29

 FINISHED 

Integrated research on DEvelopmental determinants of Aging and Longevity (IDEAL)

Start date: Feb 1, 2011, End date: Jan 31, 2016,

"IDEAL will obtain insight into the role of early life conditions affecting late-life health, disease and aging, and the role of epigenetic regulation therein. IDEAL will identify the determinants and targets of this epigenetic regulation utilizing a resource of unique human cohorts and animal studies that allow testing of hypotheses on the link between development and aging.Key objectives of IDEA ...
Read Project

 16

 FINISHED 

Introducing diagnostic applications of ‘3Gb-testing’ in human genetics (3GB-TEST)

Start date: Sep 1, 2013, End date: Aug 31, 2015,

...agnostic setting will have an enormous impact on diagnostic centres replacing many existing molecular and cytogenetic tests.Patients deserve to benefit from our vastly growing knowledge on functional genomics. 3Gb-testing is the ideal method to bring these benefits to the public. However, it is critical to avoid mistakes with respect to ethics, quality, over or mis-interpretation of data. It is es ...
Read Project

 11

 FINISHED 

European Training Network on Cancer-Induced Bone Diseases (BONE-NET)

Start date: Feb 1, 2011, End date: Jan 31, 2015,

...then seek to identify and develop molecularly-targeted therapies. BONE-NET’s primary objective will be to train 11 early-stage (ESR) and 3 experienced (ER) researchers in technical skills such as genomics, proteomics, advanced microscopical methods, animal experimentation, noninvasive in vivo imaging methodologies and drug development. None of the participating laboratories use all of these approa ...
Read Project

 11

 FINISHED 

Novel characterization of crop wild relative and landrace resources as a basis for improved crop breeding (PGR Secure)

Start date: Mar 1, 2011, End date: Aug 31, 2014,

...underpinning European food security in the face of climate change. To achieve these goals PGR Secure has four research themes: 1. Investigation of novel characterization techniques, including: (1a) Genomics, phenotyping and metabolomics, (1b) Transcriptomics, (1c) Focused Identification of Germplasm Strategy; 2. CWR and LR conservation, including: (2a) Europe-wide CWR inventory, (2b) Exemplar na ...
Read Project

 11

 FINISHED 

Prostate Research Organizations-Network of Early Stage Training (PRO-NEST)

Start date: Oct 1, 2009, End date: Sep 30, 2013,

"New and recent developments have revolutionized the prostate cancer research and clinical arenas, requiring the next generation scientists to have comprehensive knowledge and expertise in basic, clinical and applied research. PRO-NEST offers young researchers a European integrated, multi-disciplinary training programme to become an independent and all-round scientist and team leader in (prostate) ...
Read Project

 18