Glycosylation of biological molecules by covalent carbohydrate attachment is the most common and chemically varied posttranslational modification (PTM) that controls a variety of biological activities and influences pathological conditions. Several studies have connected glycosylation changes in plasmatic and cardiac proteins to the physiopathology of cardiovascular diseases (CVD).

Both ATH and Alzheimer's disease (AD) are caused by oxidative and inflammatory stress and share molecular mechanisms indicating that amyloid-β (Aβ) peptides can accumulate in the blood and may be involved in the pathogenesis of myocardial infarction (MI) and ischemia reperfusion injury (I/R injury).

The N-O-glycosylation moieties of amyloid precursor protein (APP) have been studied in the brain and cerebrospinal fluid of AD patients and healthy persons, indicating that their changes have a major influence on Aβ processing.

However, specific research on the influence of ischemic conditions on APP glycosylation and Aβ generation in MI patients is missing. This study's findings have the potential to enhance patient care by strengthening MI prediction, designing targeted therapies, and providing recommendations and guidelines for patients and healthcare professionals.

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