A three-day conference, Week of Innovative Regions Europe VI (WIRE VI), is proposed to be held in Riga during the Latvia’s Presidency of the European Union in 2015. The WIRE VI will focus on enhancing research and innovation investment as well as policy efficiency in the context of the new programming period (2014-2020). The WIRE VI will concentrate on the new specific objective of Horizon 2020 on Spreading Excellence and Widening Participation and will pay attention to the newly proposed measures to help address the innovation divide through actions on Teaming, Twinning and ERA Chairs, bringing excellence and innovation to research institutions. The links and synergies of research and innovation policy with Cohesion Policy and the specific tool of clusters will be examined, especially regarding the modalities stemming from the new legislation of the European Structural and Investment Funds. The conference will contribute to research, innovation and regional policy development following the traditions of previous conferences of WIRE series.