Recent developments in the field of innovation in European public health systems, reflected in the initiatives of the European Union and the World Health Organisation, have pinpointed the necessity of fostering cooperation and exchanges across boundaries in the healthcare sector, so as to enhance the quality, access, openness and innovation of healthcare education. Information technologies have already unfolded their potential and have proven to be successful in achieving these objectives, e.g. through the spectacular development of e-health and communities of practices worldwide. However, it is fundamental to federate and further encourage these innovations by providing a virtual meeting point for the multiplication of their impact. The WHOLE web based health organisations learning environment intends to address this need, in a sector in which multiplication of knowledge has a direct impact on societal and economic well-being of Europeans. The overall aim of the WHOLE project is therefore to develop and consolidate a European Virtual Academy of Innovation in Health, which: analyses good practices and investigate transferability and scalability of innovation in public health, promotes sustainable collaboration in public health training across boundaries, involves the primary target groups, i.e. students and healthcare professionals, in a European Master degree for intercultural and societal healthcare studies, fosters the use of ICT for learning, exchange, collaboration in the healthcare sector, multiplies and consolidates dialogue arenas among policy makers, students, researchers, healthcare professionals and citizens. The virtual learning environment to be set up will include learning resources repositories, learners' management facilities, virtual communities and other social software facilities. The Master degree will be structured in 6 modules, i.e.: health inequalities in Europe, the perspective of an integrated healthcare, strengthening of citizens rights in relation to healthcare institutions and professional caregivers, addressing also cross border healthcare in Europe, health promotion and chronic disease prevention, healthcare coordination and crisis management in catastrophes, migration, healthcare and social services. A scientific quality committee will support project partners in ensuring quality. The main expected results are: the report on "Professional development goals and ICT in the transformation of the healthcare sector", the European virtual academy and Virtual learning environment operational, at least 50 students and healthcare professionals involved in the Master degree for intercultural and societal healthcare studies, the white paper "Towards a European framework for collaboration and innovation in public health".