Description The REWIRE project develops, integrates and field tests an innovative rehabilitation platform based on virtual reality. The platform allows patients, discharged by the hospital, to continue their intensive rehabilitation at home under remote monitoring by the hospital itself. The patient sees on the display himself or an avatar moving and interacting in real-time with a virtual game with his movements tracked in real-time. Game variety of scenarios, balanced scoring system, quantitative exercise evaluation, audio-visual feed-back aims to maximize the patient’s motivation. On top of that, a virtual community is setup to educate and motivate the patients. The patient’s daily activity is monitored by a Body Sensor Networks and his activity is profiled through eigenbehaviors. Environmental, physiological and motion data are combined to tune the rehabilitation exercise level, to assess potential risks and advice clinicians on the therapy. Data mining in the Networking Station discovers common features and trends of rehabilitation treatment among hospitals and regions. A pilot is taking place not only to clinically evaluate the effectiveness and suitability of REWIRE, but also to find out which  model is the most appropriate to seamlessly connect long-term at home rehabilitation to that at hospital. Appropriate service settings and adequate business models are also being looked at.