Regulating nuclear organisation in telomere maintenance and DNA repair: the role of SUMO modification
(SUMO and chromatin)
Start date: Mar 1, 2008,
End date: Feb 28, 2010
PROJECT
FINISHED
The organisation of the genome into separate domains and sub-compartments through higher order chromatin structure is an important means by which eukaryotic cells control nuclear processes such as DNA transcription and repair. Recent evidence has implicated sumoylation as an important regulator of global nuclear architecture as well as allied processes such as telomere maintenance and DNA damage repair. Using the yeast Saccharomyces cerevisiae as a model organism to look at nuclear dynamics in vivo, we aim to elucidate the mechanism by which SUMO modification regulates these processes.
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Coordinator
- Susan Gasser
- Maulbeerstrasse 66 4058 BASEL (Switzerland)
Details
- 100% € 179 297,73
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FP7-PEOPLE
- Project on CORDIS Platform