The specific and ultimate goal of the REMPARK project is to develop a PHS with closed loop detection, response and treatment capabilities for management of Parkinson's Disease (PD) patients at two levels:\n\nAt the first level, the project will develop a wearable monitoring system able to identify in real time the motor status of the PD patients, and evaluating ON/OFF/Dyskinesia status, with sensitivity greater than 80% and specificity greater than 80% in operation during ambulatory conditions and will also develop a gait guidance system able to help the patient in real time during their daily activities.\n\nAt a second level, the intelligent analysis of data provided by the first level, supported with a disease management system will allow the neurologist in charge to access accurate and reliable information to decide about the treatment that best suits the patient, improving the management of their disease, in particular to adjust so called therapeutic window.\n\nTo achieve this global goal, four main objectives need to be achieved:\n• Identification of motor status in real time\n• Development of a gait guidance system\n• Development of a user interface to collect direct feedback from the patient\n• Development of a server to allow interaction with the doctor in charge and track the evolution of the patient's condition.\n\nREMPARK system will be tested in 60 real patients from four medical centres. The consortium is formed by medical and technical renowned specialists, and PD patients are represented through the participation of the European Parkinson's Disease Association.