Patient empowerment is considered a potential tool to reduce healthcare costs and improve efficiency of the health systems, reinforcing healthcare quality. Patient empowerment has become an element of high priority in the EU health strategy, supported by national and regional health authorities.Building on already existing e-health platforms and services in the participating regions, the PALANTE project focuses on the implementation, scaling up and optimisation of 7 demonstration pilots based on the concept of secure and user friendly online access by citizens to their medical/health data. The main goal of this proposal is to empower patients so they will be able to make informed decisions about their health, take an active role in their care and collaborate effectively with their healthcare team thanks to the use of information and communication technologies.The PALANTE Project considers 7 new pilots in 6 countries (7 regions) and 2 additional on-going pilots in 2 other countries. The pilots have been carefully selected to cover different levels of patient empowerment. Globally, the project mobilizes 21 partners in 10 different countries, and 69.550 new users. Pilot teams include public and private partnerships ensuring all the key stakeholders involved in eHealth provision.All the pilots address the issue of patient's secure access to their own health information. Additionally, 5 of these pilots deal with integrated chronic disease management support, including comprehensive self-learning, education and monitoring systems that will be validated for diabetes, chronic heart failure, severe arthritis and respiratory diseases. They cover a wide range of services with different grade of complexity and thus different number of patients according to each service.The Project also takes into account the challenge of patients' mobility by addressing interoperability among pilots. Some partners of PALANTE consortium are directly involved in EpSOS project.