New Concepts for Utilizing a Ubiquitous (Non-)Func.. (C-H ACTIVATION)
New Concepts for Utilizing a Ubiquitous (Non-)Functional Group - C-H Bond Activation for Increased Efficiency in Organic Synthesis
(C-H ACTIVATION)
Start date: Dec 1, 2010,
End date: Nov 30, 2015
PROJECT
FINISHED
C-H activations and related reactions can potentially revolutionize the way organic molecules are made and allow a more efficient use of earth's natural resources. Despite the rapid progress of the last couple of years, many problems like limited scope, extreme reaction conditions (temperature, excess of reagents) or low reactivities and selectivities remain in many cases. In this comprehensive proposal containing a number of projects and work packages, we want to develope new C-H activation methods 1) for the efficient synthesis of heterocycles, 2) for the activation of unactivated C(sp3)-H bonds, 3) by employing newly designed Fe-NHC complexes and 4) demonstrating the application of C-H activation for the functionalization of metal-organic frameworks (MOFs). The realization of these goals would render organic synthesis greener and more efficient and would have an impact on the preparation of compounds in academia and industry.
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