MUNDUS is an assistive framework for recovering direct interaction capability of severely motor impaired people based on arm reaching and hand function. Most of the solutions provided by Assistive Technology for supporting independent life of severely impaired people completely substitute the natural interaction with the world, reducing their acceptance. Human dignity and self-esteem are more preserved when restoring missing functions with devices safeguarding self perception and first hand interaction while guaranteeing independent living.MUNDUS uses any residual control of the end-user, thus it is suitable for long term utilization in daily activities. Sensors, actuators and control solutions adapt to the level of severity or progression of the disease allowing the disabled person to interact voluntarily with naturality and at maximum information rate.MUNDUS targets are the neurodegenerative and genetic neuromuscular diseases and high level Spinal Cord Injury.MUNDUS is an adaptable and modular facilitator, which follows its user along the progression of the disease, sparing training time and allowing fast adjustment to new situations. MUNDUS controller integrates multimodal information collected by electromyography, bioimpedance, head/eye tracking and eventually brain computer interface commands. MUNDUS actuators modularly combine a lightweight and non-cumbersome exoskeleton, compensating for arm weight, a biomimetic wearable neuroprosthesis for arm motion and small and lightweight mechanisms to assist the grasp of collaborative functional objects identified by radio frequency identification. The lightness and non cumbersomeness will be crucial to applicability in the home/work environment.Specific scenarios in the home and work environment will be used to assess, subjectively and quantitatively, the usability of the system by real end-users in the living laboratory facility.