Musculoskeletal diseases (MSD) and related disorders are often considered as an inevitable consequence of aging and they account for the largest fraction of temporary and permanent disability. It is the leading cause of disability in the EU and accounts for more than half of all chronic conditions in people over 50 years of age in developed countries. The burden of MSD and related disorders presents thus a compelling argument for greater understanding through expanding research and training of experts. As recognized by the EU strategic approach white paper (2007) – “Together for health” and the subsequent green paper (2008) – “On the European workforce for health”, the advances in sciences and the rapid developments in new technologies are revolutionizing how we promote health and predict, prevent and treat illness. The goal of Multi-scale Biological modalities for physiological human articulation (MultiScaleHuman) is to research by training a body of early stage researchers (ESR) and experienced researchers (ER) in the creation of a multi-scale biological data visualization and knowledge management system for improved understanding, diagnosis and treatment of physiological human articulation. MultiScaleHuman will narrow its ambitious research towards a very important and challenging healthcare problem of MSD and related disorders. This will be achieved through initiating a network of ESR/ER with training provided from a three-sector-research consortium which involves academic (education), hospital (social actors) and private (industry) sectors. MultiScaleHuman will provide a unique training program, from technical to complementary skills learning by fully exploiting the training opportunities that Marie Curie ITN provides and by building a consortium of partners that brings multi-disciplinary skills in the understanding and treatment of physiological articulations in MSD and related disorders.