Water4Crops provides a combination of technical improvements in the field of bio-treatment and agricultural water use within a transdisciplinary identification of novel agri-business opportunities. Water4Crops aims at: a) developing innovative biotechnological wastewater treatments for improved water recycling, b) initiating the co-creation of alternative combinations of bio-treatment, recycling of high value elements, and combinations for bioproducts leading to a better commercialization of biotechnology and agricultural products in Europe and India, c)improving water use efficiency at field level through agronomics, plant breeding and locally adapted new irrigation technologies and accurate crop water requirement measurements techniques. Water4Crops will boost bio-based economy by applying a double track approach.First a comprehensive set of key Green-Economy technologies for: 1) valorization of volatile fatty acids; 2) obtaining: natural antioxidants (polyphenols), biopolymers (PHAs), energy (biomethane); 3) new substances for selective recovery of valuable products from wastewater; 4) tailoring effluent properties from decentralized innovative bioreactors; 5) low bio-sludge production by SBBG Reactors; 6) removal of organopollutants by nanobiocatalysts; 7) reduced clogging of wetlands; 8) virus monitoring detection assays; 9) suitable precision irrigation systems for reclaimed water; 10) new monitoring for increase crop water productivity; 11) understanding the genetic mechanisms regulating drought-adaptive traits across maize, sorghum, millet and tomato; 12) optimized waste water related combinations of species/genotypes x environment x management. Second, new product market combinations will be identified. The co-creation process will be organized by two Mirror cases (Emilia Romagna area in Italy and Hyderabad region in India) within a specific Science-Practice Interface (INNOVA platforms). Developing the new applications and business opportunities with regional enterprises and stakeholder will move India and Europe towards a Green Economy.