"Molecules containing the element oxygen can be further characterized by the distributions of the stable oxygen isotopes. In some cases, these isotopes have an anomalous distribution, which is evidence of Mass Independent Fractionation (MIF). MIF has become a powerful research tool in earth system science and its use is expected to spread from the core science disciplines to industrial applications. With INTRAMIF, we bring together experts from atmospheric and climate research, hydrology, oceanography and molecular physics. 13 ESR projects from these disciplines are connected by the common theme of MIF. Sharing expertise and world-class facilities will allow the individual groups to do research that would otherwise be impossible. This will create a center of excellence for MIF research in Europe. The associated industrial partners of INTRAMIF will integrate the research and training programs with ‘real-world’ opportunities, including commercialization of new techniques and the application of MIF to solve questions on water supplies and food authentication. The broad scientific program allows us to combine specialized training at the host institutions with a unique interdisciplinary and intra-sector network training program on the climate system involving associated partners from the industrial, political and economic sectors. The strong interest from our associated partners documents the need for highly qualified scientists with a wide interdisciplinary background. INTRAMIF will educate the next generation of scientists that can tackle new challenges to society in a changing climate."