ICT developments both enable and also enforce large-scale, highly-connected systems in society and industry. Knowledge to cope with these emerging systems is lacking. HYCON2 will stimulate and establish the long-term integration of the European research community, leading institutions and industry in the strategic field of control of complex, large-scale, and networked dynamical systems. It will interconnect scattered groups to create critical mass and complementarity, and will provide the necessary visibility and communication with the European industries. HYCON2 will assess and coordinate basic and applied research, from fundamental analytical properties of complex systems to control design methodologies with networking, self-organizing and system-wide coordination. HYCON2 has identified several applications domains to motivate, integrate, and evaluate research in networked control. These domains are ground and aerospace transportation, electrical power networks, process industries, and biological and medical systems. Benchmarking will serve as a tool for testing and evaluating the technologies developed in HYCON2 and for stimulating and enforcing excellence by the identification and adoption of best practices. In particular, two show-case applications corresponding to real-world problems have been selected in order to demonstrate the applicability of networked control and the need for research in control. As no substantial technological breakthrough can be achieved without preparing the proper cultural background, a further important objective of HYCON2 is to spread and disseminate excellence through multi-disciplinary education at the graduate and undergraduate level. The proposed research, integration and dissemination program will make Europe both the prominent scientific and the industrial leader in the area of highly complex and networked control systems, therefore posing Europe in an extraordinary position to exploit their impact in economy and society.