Challenge: Health-TIES addresses Europe’s largest health challenges: an ageing population and the sustainability of the healthcare system. This cross-border challenge needs a collaborative approach!Third revolution: True collaboration between medical scientists, engineers, healthcare providers, industry and government is the key to innovation in healthcare (the “third revolution”). Health-TIES is at the forefront: a transnational consortium in medical technology comprising four top regions in biosciences, technology and entrepreneurship: Biocat (Catalonia), Medical Delta (West Netherlands), Oxford/Thames Valley, Canton de Zurich and a mentoring region Észak-Alföld (Hungary).Common goals: To maximise the impact of innovation and RTD on healthcare, Health-TIES will stimulate joint science, education and state-of-the-art infrastructure; and boost the Healthcare Technology Innovation Cycle.S&T meet patients: Breakthroughs in molecular technology, imaging, and drug design have created new avenues for prevention (risk factor identification, early diagnosis) and more effective treatment. Health-TIES will apply these to Cardiovascular diseases, Cancer, Neurodegenerative diseases, Immunology & Infectious diseases.Accelerate innovation: Health-TIES will accelerate the Healthcare Technology Innovation Cycle, which connects engineers and medical professionals, scientists and entrepreneurs, developers and end-users. Policy makers will be engaged in developing the RTD agenda.Analyse, integrate, disseminate: Health-TIES activities include: analysing innovation performance; attracting SMEs; exchanging staff and students; entrepreneurial training; connecting stakeholders; involving end-users in RTD; sharing best-practices through a Virtual Reference Region and ICT-tools.Better health(care): Health-TIES will contribute to improved health of EU citizens, better-equipped medical doctors, more efficient and effective healthcare systems, and an economically viable sector.