Medical conditions (MC), such as obesity, diabetes and cardiovascular disorders are more prevalent in people with major psychiatric disorders (major depressive disorder, bipolar disorder, schizophrenia). The relationship between mental and physical disorders is complex and not clearly understood. Although it is well reported that MC have a high impact in the lifespan and mortality of people with psychiatric disorders. Recent studies support the hypothesis that there may be shared aetiological factors, including environmental and genetic factors, between psychiatric disorders and MC. In a cross-sectional study (PISMA-ep) of a representative sample of the Andalusian population, 4,500 individuals donated a biological sample for genetic studies. Diagnosis of psychiatric disorders was ascertained using the Mini International Neuropsychiatric Interview (MINI). In addition to psychological, social and sociodemographic information, a wealth of detailed data on chronic, comorbid MC were collected using a validated checklist. OBJECTIVES: 1) examine the prevalence and characteristics of MC in individuals with major psychiatric disorders and compare them with psychiatrically healthy controls; 2) DNA extraction and genotyping of candidate genes/polymorphisms 3) explore genetic and environmental factors in comorbid mental and physical diseases. METHODS: we will use available statistical packages to determine the frequency of comorbid MC in psychiatric disorders, stratifying by social and environmental risk factors. We will perfom DNA extraction and genotyping of candidate genes in the total sample. EXPECTED RESULTS: we should expect to find higher prevalence of MC in people with psychiatric disorders, as well as genetic and environmental increased risk in individuals with a history of comorbid MC in psychiatric disorders.