This proposal has been elaborated by a consortium of 35 partners coming from 27 European countries and including scientists, government institutions and authorities, NGOs and industry. The main goal is to develop a coherent approach to HBM in Europe as requested by ACTION 3 of the EU Environment and Health Action Plan through coordination of ongoing and planned HBM activities. The project will exploit existing and planned HBM projects and programmes of work and capabilities in Europe. The consortium will investigate what is needed to advance and improve comparability of HBM data across Europe. Work prepared under DG Research and DG Environment activities dealing with development, validation and use of novel biomarkers including non-invasive markers and effect markers will be exploited. Through close collaboration with similar initiatives in the field of Health - such as the EU Health Examination Survey - appropriate economies and efficiencies will be assessed. Key issues such as Ethics and human Biobanks will be addressed. The project will deliver a number of key outputs including: 1. Tested Proofs of Concept and/or Demonstration project assessing the feasibility of a coordinated approach, including strategies for data interpretation & integration with environmental and health data. 2. A rationale and strategy for communication and dissemination of information, results and key messages to all stakeholders from the public to policy makers 3. Training and capacity building will aim to promote knowledge and experience exchange and development in the field of HBM within Europe A common understanding within all parties involved on the potential of HMB in supporting and evaluating current/future policy making (including e.g. REACH) and for environmental health awareness raising will be promoted This project aim is to significantly advance the process towards a fully operational, continuous, sustainable and scientifically sound EU HBM programme.