"This project deals with the necessity in the EU to build a system that enables entrepreneurs or academia Technology Transfer Offices to achieve, in the best conditions of rapidity and cost effectiveness, the Industrial Proof of Concept (I-PoC) that enables a real economic valorization of Research achievements (Scientific Proof of concept-Sci-PoC). This early stage development is considered world wide as the weak ring in the chain of innovation.The objective is to design a Joint Action Plan between Consortium members and other EU Bio-Regions, that will enable any actor responsible for an early stage development to beneficiate from a variety of shared resources that will accelerate the process, make it safer and cost effective.The central tool (WP4) for this is twofold: (1) A network of maturation systems that can take in charge the pre-development stage without creating a company. The existing examples are Go-Bio in Berlin, Bioline in Israel, and several systems in the US. (2) A network of Incubation systems that can, collectively, select, mentor, finance and nurture start-up companies, wherever they are located.The second common tool (WP5) to be built is a network of high grade facilities, where a large part of the technical experimentation of the maturation process could be done. The third tool (WP3) is probably the most valuable: Bio CT aim at building common tools for enabling maturation projects to find the personnel they need, through internal EU mobility or thanks to an attractive Reverse Brain Drain set of measures.The three tools will be linked in a Joint Action Plan designed in the form of a Business Plan in which the financing and Governance parameters will be particularly addressed. Such thinking cannot be done over all domains of Biotechnology. In this project we will choose examples in the Translational medicine. All Bio-Clusters Partners have the full confidence and financial support from their Regional Authorities, which consider them as major actors for structuring their Bio-Region."