Background: Healthcare systems worldwide are increasingly unable to meet growing demand for and cost of healthcare. Changing demographics leading to increasing demand for services of increasing cost exacerbate this problem. Thus,healthcare costs are an increasingly unaffordable share of economically constrained national budgets.More specifically, an average 10% of healthcare costs are for acute and intensive care, which equates ~1% of GDP in many EU countries – a significant share. Highly trained doctors and nurses are the scarce and costly resource in critical and acute care. Thus,improving care and productivity in intensive and acute care units by merging engineering, technology and medicine presents a significant research and economic opportunity and challenge.The Specific Problem: While acute and critical care doctors have a range of technology and sensors at their disposal, their ability to rapidly provide the more consistent, patient-specific care required to improve productivity and patient outcomes is limited. In particular, they are unable to take full advantage of the wealth of data they are presented to best utilise the pumps,ventilators and other technologies used to provide care.The Solution: The application of clinically validated computer models of patient physiology that can be made patient-specific using data at their bedside can integrate this patient data into a clear physiological picture of patient-specific condition and response to treatment, as well as help guide therapy. These computer models can be combined with automation technology to improve both the productivity and quality of care, alleviating demand on scarce and costly personnel.Proposed Answer: Model-based Therapeutics (MBT) is an emerging field combining computer models of human physiology, clinical data and automation of care to create innovative solutions to major clinical problems. This project will create an international MBT consortium centered on 3 major core projects.