Cytokine Receptor Signaling Revisited: Implementing novel concepts for cytokine-based therapies
(CYRE)
Start date: Feb 1, 2014,
End date: Jan 31, 2019
PROJECT
FINISHED
"Cytokine receptor signaling is an essential part of the intercellular communication networks that govern key physiological processes in the body. Cytokine dysfunction is associated with numerous pathologies including autoimmune disorders and cancer, and both cytokines and cytokine antagonists have found their way into the clinic. Yet, there are still many unfulfilled promises and opportunities. In this project we will reinvestigate key aspects of cytokine receptor activation and signaling using novel insights and techniques recently developed in our laboratory. This will include the AcTakine concept for cell-specific targeting of cytokine activity, and applications of our MAPPIT, KISS and Virotrap toolboxes to systematically map protein interactions involved in cytokine signaling. We expect to obtain important new insights, both in fundamental and in applied medical sciences."
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Coordinator
VIB
€ 2 487 728,50- Rik Audenaert
- Rijvisschestraat 9052 Zwijnaarde - Gent (Belgium)
Details
- 100% € 2 487 728,40
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FP7-IDEAS-ERC
- Project on CORDIS Platform