The vision of the proposed GRANATUM project is to bridge the information, knowledge and collaboration gap among biomedical researchers in Europe (at least) ensuring that the biomedical scientific community has homogenized, integrated access to the globally available information and data resources needed to perform complex cancer chemoprevention experiments and conduct studies on large-scale datasets. In this way, the GRANATUM initiative will facilitate the social sharing and collective analysis of biomedical experts' knowledge and experience, as well as the joint conceptualization and design of scalable chemoprevention models and simulators, towards the enablement of collaborative biomedical research activities beyond geographical. - the innovative GRANATUM Framework, Architecture and Platform for socially interconnecting and semantically linking the cancer chemoprevention biomedical researchers, data, resources and services; - the GRANATUM Semantic Model that constitutes a common ontological reference model for the semantic annotation, sharing and interconnection of globally available biomedical resources, such as EHR databases, digital libraries and archives, online communities and discussions; - a set of GRANATUM Research Collaboration Showcases and Experiments in Cancer Chemoprevention that will validate and prove the concepts and tools of the proposed GRANATUM initiative; - the GRANATUM Methodology that constitutes a step-by-step cookbook with methodological adoption guidelines for leveraging the quality of the integrative biomedical research in cancer chemoprevention; - Wide-scale dissemination and exploitation of the project results to the European academic, scientific and industrial stakeholders in the enlarged Europe and beyond. Led by Fraunhofer FIT, the GRANATUM consortium consists of eight (8) partners, from five (5) EU member states, i.e. Ireland, Italy, Germany, Cyprus and Greece.