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Over 40 European Projects Found

Searched on 125080 European Projects

 FINISHED 

A Systems medicine approach to chronic inflammatory disease (SYSCID)

Start date: Jan 1, 2017, End date: Mar 31, 2022,

"The SYSCID consortium aims to develop a systems medicine approach for disease prediction in CID. We will focus on three major CID indications with distinct characteristics, yet a large overlap of their molecular risk map: inflammatory bowel disease, systemic lupus erythematodes and rheumatoid arthritis. We have joined 15 partners from major cohorts and initiatives in Europe (e.g.IHEC, ICGC, Twins ...
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 16

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Brain-Specific, Modular and Active RNA Therapeutics (B-SMART)

Start date: Jan 1, 2017, End date: Dec 31, 2021,

The overall objective of B-SMART is: 1. to design modular nanoparticles, 2. to manufacture them via a quality-by-design protocol, 3. to achieve delivery of therapeutic RNAs to the brain and treat neurodegenerative diseases. I. To design modular nanoparticles consisting of o an active RNA payloado established (lipid-based), emerging (trigger-responsive polymer-based) or exploratory (extracellular v ...
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 9

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Mechanisms and regulation of inflammasome-associated programmed cell death (PyroPop)

Start date: Jan 1, 2017, End date: Dec 31, 2021,

Programmed cell death is essential for homeostasis, and its deregulation contributes to human disease. Inflammasome-induced pyroptosis of infected macrophages contributes to host defense against infections, but the concomitant release of inflammatory danger signals and leaderless cytokines is detrimental in chronic inflammatory diseases. The central hypothesis of the PyroPop ERC Consolidator proje ...
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 1

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Memory in biological regulatory circuits (YEASTMEMORY)

Start date: Oct 1, 2016, End date: Sep 30, 2021,

The emergence of intelligence –the ability to remember and analyze data to make decisions– was a milestone in evolution. Intelligence and memory are usually associated with plastic neuronal connections in higher organisms. However, new discoveries hint that a rudimentary form of intelligence is rooted in networks that regulate gene expression in a wide range of organisms, including bacteria and ye ...
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 1

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Clathrin-mediated endocytosis in plants: mechanistic insight into the TPLATE REcycling compleX and its interplay with AP-2 (T-Rex)

Start date: Jul 1, 2016, End date: Jun 30, 2021,

Cells communicate with the outside world through proteins anchored in their plasma membrane and hereto constantly adjust their plasma membrane (PM) proteome. In this adjustment process, removing proteins from the PM mainly occurs through clathrin-mediated endocytosis (CME). Mechanistically however, this process remains poorly understood in plants.A recent study from my group has shown that, in con ...
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 1

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Novel approaches to determining the function of tissue-specific regulatory T cells (Tissue-Tregs)

Start date: Jun 1, 2016, End date: May 31, 2021,

Regulatory T cells (Tregs) are formed through the expression of the transcription factor Foxp3 in T cells, resulting in the rewiring of the cell function into an immunosuppressive phenotype. Recently, it has been proposed that Tregs also have additional tissue-specific physiological roles when resident in different tissues. For example, tissue-specific Tregs residing in the muscle and adipose tiss ...
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 1

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Releasing the full potential of Instruct to expand and consolidate infrastructure services for integrated structural life science research (INSTRUCT-ULTRA)

Start date: Jan 1, 2017, End date: Dec 31, 2020,

Instruct-Ultra aims to advance the scope and efficiency of implementation of Instruct and consolidate the foundations for long-term sustainability. This will be achieved through specific objectives: expand Instruct membership to new Member States and increase global links; engage new user communities; improve efficiencies in service delivery; improve data capture and management; adjust the scale a ...
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Preparation for EMPHASIS: European Infrastructure for multi-scale Plant Phenomics and Simulation for food security in a changing climate (EMPHASIS-PREP)

Start date: Jan 1, 2017, End date: Dec 31, 2020,

Sustainable food security and increasing availability of plant biomass for human nutrition and bioindustries is the key challenge for the coming decades. The analysis of crop performance with respect to structure, function, quality and interaction with the environment (“phenotyping”) remains the bottleneck for the exploitation of crop genetic diversity required for the enhancement of plant product ...
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 9

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Maintaining synaptic function for a healthy brain: Membrane trafficking and autophagy in neurodegeneration (RobustSynapses)

Start date: Jan 1, 2016, End date: Dec 31, 2020,

Neurodegeneration is characterized by misfolded proteins and dysfunctional synapses. Synapses are often located very far away from their cell bodies and they must therefore largely independently cope with the unfolded, dysfunctional proteins that form as a result of synaptic activity and stress. My hypothesis is that synaptic terminals have adopted specific mechanisms to maintain robustness over ...
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 1

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Breast CAncer STratification: understanding the determinants of risk and prognosis of molecular subtypes (B-CAST)

Start date: Sep 1, 2015, End date: Aug 31, 2020,

Breast tumours are heterogeneous, and result from the complex interplay of multiple lifestyle/environmental and genetic risk factors. Through the EU-funded COGS project, we have identified a large number of germline variants that influence the risk of breast cancer. In combination, these variants can identify women at wide ranges of genetic risk, even in the absence of family history of breast can ...
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 13

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Environmental modulators of the immune cell balance in health and disease (ENVIROIMMUNE)

Start date: Aug 1, 2015, End date: Jul 31, 2020,

The incidence of autoimmune diseases in developed societies is increasing at high rates, but the underlying cause for this phenomenon has not been elucidated yet. Since the genetic architect remains considerably stable, this increase is likely associated with changes in the environment. Autoimmunity is linked to an imbalance of pro-inflammatory Th17 cells and anti-inflammatory Foxp3+ regulatory T ...
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 2

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The determinants of cross-seeding of protein aggregation: a Multiple TANGO (MANGO)

Start date: Jun 1, 2015, End date: May 31, 2020,

Amyloid-like protein aggregation is a process of protein assembly via the formation of intermolecular β-structures by short aggregation prone sequence regions. This occurs as an unwanted side-reaction of impaired protein folding in disease, but also for the construction of natural nanomaterials. Aggregates appear to be strongly enriched in particular proteins, suggesting that the assembly process ...
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 1

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Bacterial Amyloid Secretion: Structural Biology and Biotechnology. (BAS-SBBT)

Start date: Jun 1, 2015, End date: May 31, 2020,

Curli are functional amyloid fibers that constitute the major protein component of the extracellular matrix in pellicle biofilms formed by Bacteroidetes and Proteobacteria. Unlike the protein misfolding and aggregation events seen in pathological amyloid diseases such as Alzheimer’s and Parkinson’s disease, curli are the product of a dedicated protein secretion machinery. Curli formation requires ...
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 1

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Unraveling the regulatory network of developmental programmed cell death in plants (PROCELLDEATH)

Start date: Apr 1, 2015, End date: Mar 31, 2020,

Programmed cell death (PCD) is a fundamental biological process that actively terminates a cell’s vital functions by a well-ordered sequence of events. In both animals and plants, various types of PCD are crucial for development, health, and the responses to various stresses. Despite their importance, only little is known about PCD processes and their molecular control in plants. Still, an intrica ...
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 1

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Alzheimer Disease - gut connection (AD-gut)

Start date: Apr 1, 2016, End date: Mar 31, 2020,

Alzheimer’s disease (AD) is the leading cause of dementia in the Western world and to date no cure nor any preventive strategy are available for this neurodegenerative disorder. Bacterial 16S rRNA sequencing from fecal samples revealed a remarkable shift in the gut microbiota of conventionally-raised AD mice compared to healthy, wild-type mice. Based on these findings, we generated germ-free Alzhe ...
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 6

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Exploiting Protein Complexes that Induce Cell-death (EPIC)

Start date: Jan 1, 2016, End date: Dec 31, 2019,

The formation of specific protein complexes are key events in life-and-death decisions made by cells. Inappropriate decisions underpin a plethora of disease conditions from degenerative diseases to cancer while the role of the complexes in these processes make them important therapeutic targets. Our ability to develop small molecules to target death-inducing protein complexes has been hampered by ...
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 5

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Promoting SINgle cell GEnomics to explore the ecology and evolution of hidden microeuKaryotes (SINGEK)

Start date: Jan 1, 2016, End date: Dec 31, 2019,

Environmental microbial surveys have revealed a remarkable diversity of microeukaryotic life in most ecosystems, the majority of which had previously escaped detection. From an ecological point of view this work highlighted our ignorance of critical microbial players in natural environmental processes, including primary production, biogeochemical cycling and trophic interactions such as parasitism ...
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 9

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MASS Spectrometry TRaining network for Protein Lipid adduct ANalysis (MASSTRPLAN)

Start date: Oct 1, 2015, End date: Sep 30, 2019,

MASSTRPLAN will train the next generation of interdisciplinary research leaders in advanced molecular analytical techniques to detect oxidized phospholipids & proteins in biological & clinical samples, evaluate their biochemical roles in inflammation, and translate these findings to develop new diagnostic tools. Chronic inflammatory diseases such as diabetes, cardiovascular disease (CVD) & cancer ...
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 12

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ELIXIR-EXCELERATE: Fast-track ELIXIR implementation and drive early user exploitation across the life-sciences. (ELIXIR-EXCELERATE)

Start date: Sep 1, 2015, End date: Aug 31, 2019,

The life sciences are undergoing a transformation. Modern experimental tools study the molecules, reactions, and organisation of life in unprecedented detail. The precipitous drop in costs for high-throughput biology has enabled European research laboratories to produce an ever-increasing amount of data. Life scientists are rapidly generating the most complex and heterogeneous datasets that scienc ...
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 47

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Cellular Hypoxia Alters DNA MEthylation through Loss of Epigenome OxidatioN (CHAMELEON)

Start date: Sep 1, 2014, End date: Aug 31, 2019,

"DNA methylation was originally described in the 1970s as an epigenetic mark involved in transcriptional silencing, but the existence of DNA demethylation and the enzymes involved in this process were only recently discovered. In particular, it was established that TET hydroxylases catalyze the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) through a reaction requiring oxyg ...
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 1

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Gamification of participatory science for training and education purposes (GAPARS)

Start date: Jan 1, 2017, End date: Jun 30, 2019,

Creating effective ways for citizen science is immensely important. Scientists in all fields increasingly rely on active public participation for experiments and analyses of complex and/or massive data, and the outreach and education possibilities of citizen science are enormous.Yet there are three key issues for any citizen science project: (i) reach out to a sufficiently large audience, (ii) low ...
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 9

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Aberrant RNA degradation in T-cell leukemia (ART)

Start date: May 1, 2014, End date: Apr 30, 2019,

"The deregulation of transcription is an important driver of leukemia development. Typically, transcription in leukemia cells is altered by the ectopic expression of transcription factors, by modulation of signaling pathways or by epigenetic changes. In addition to these factors that affect the production of RNAs, also changes in the processing of RNA (its splicing, transport and decay) may contri ...
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 1

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From zebrafish to man Modifying amyotrophic lateral sclerosis (ALS): translation of biology into therapy (ModifALS)

Start date: May 1, 2014, End date: Apr 30, 2019,

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor neurons. As for other neurodegenerative disorders, translation of newly acquired biological insights into therapies has been difficult. In the current project we intend to contribute to the development of therapeutic approaches for ALS. We want to generate novel models, identify new therapeutic targets for interv ...
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 1

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Function of Chemosensory Circuits (CHEMOSENSORYCIRCUITS)

Start date: Apr 1, 2014, End date: Mar 31, 2019,

Smell and taste are the least studied of all senses. Very little is known about chemosensory information processing beyond the level of receptor neurons. Every morning we enjoy our coffee thanks to our brains ability to combine and process multiple sensory modalities. Meanwhile, we can still review a document on our desk by adjusting the weights of numerous sensory inputs that constantly bombard o ...
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 2

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Exploring the targeted delivery of biopharmaceuticals enabled by glycosylation control (GlycoTarget)

Start date: Mar 1, 2014, End date: Feb 28, 2019,

Most biotechnological therapeutics used in the clinic today and under current development, are of protein nature. Eukaryotic expression systems (such as yeasts and mammalian cells) for these therapeutic proteins add carbohydrate moieties (glycans) to the proteins, and these glycans strongly modulate the protein's in vivo biodistribution and therapeutic efficacy. Until recently, no adequate tools w ...
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 1

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Atlas of leaf growth regulatory networks in MAIZE (AMAIZE)

Start date: Feb 1, 2014, End date: Jan 31, 2019,

"Understanding how organisms regulate size is one of the most fascinating open questions in biology. The aim of the AMAIZE project is to unravel how growth of maize leaves is controlled. Maize leaf development offers great opportunities to study the dynamics of growth regulatory networks, essentially because leaf development is a linear system with cell division at the leaf basis followed by cell ...
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 1

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Cytokine Receptor Signaling Revisited: Implementing novel concepts for cytokine-based therapies (CYRE)

Start date: Feb 1, 2014, End date: Jan 31, 2019,

"Cytokine receptor signaling is an essential part of the intercellular communication networks that govern key physiological processes in the body. Cytokine dysfunction is associated with numerous pathologies including autoimmune disorders and cancer, and both cytokines and cytokine antagonists have found their way into the clinic. Yet, there are still many unfulfilled promises and opportunities. I ...
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 1

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The Algal Microbiome: Friends and Foes (ALFF)

Start date: Jan 1, 2015, End date: Dec 31, 2018,

Algal aquaculture is developing exponentially worldwide, with multiple applications in the food, chemical and pharmaceutical industries. Current research in algal biotechnology mostly focuses on metabolite discovery, aquaculture yield improvement and engineering bottlenecks. However, agronomical experience shows that controlling the interaction of land crops with mutualistic or pathogenic microbes ...
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 10

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Ribosome defects in cancer (RIBOCANCER)

Start date: Jan 1, 2014, End date: Dec 31, 2018,

"Cancer cells are defective in vital cell functions such as cell cycle control and response to growth signals. We found that cancer cells acquire defects in yet another vital function: translation of mRNA into proteins. We saw that 9.8% of children with T-cell leukemia (T-ALL) harbor acquired mutations in the ribosome, the cellular protein translation factory. We found mutations in RPL10, RPL5 and ...
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 2

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Toll-Like Receptor 4 activation and function in diseases: an integrated chemical-biology approach. (TOLLerant)

Start date: Jan 1, 2015, End date: Dec 31, 2018,

Based on an international team derived from the COST action BM1003 (www.cost-bm1003.info, 2011-2014) and thus relying on consolidated group interactions and synergies and on a unique combination of chemistry, biology, biophysics, biochemistry and pharmacology expertise, the TOLLerant project aims to gain information on molecular aspects of TLR4 activation and signaling by using synthetic and natur ...
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 10

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Endothelial Gluconeogenesis: a novel target for tumor anti-angiogenesis? (EC GNG metabolism)

Start date: Jan 1, 2017, End date: Dec 31, 2018,

Angiogenesis promotes tumor progression and metastasis; unfortunately current anti-angiogenic strategies targeting endothelial growth factors suffer from limited efficacy and toxicity. The host laboratory pioneered the novel concept that blood vessel forming endothelial cells (ECs) reprogram their metabolism to become glucose-addicted and rely on glycolysis to generate ATP required for angiogenesi ...
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Migration - Challenge of Modernity

Start date: Dec 31, 2016, End date: Dec 30, 2018,

"Migration - Challenge of Modernity" is two stages Erasmus+ project aiming cover, explore, discuss and deal with integration related challenges linked to the migration process. Creating network of the civic organizations working or willing to work in the field, promote new tools and methodology among youth workers and NGO workers in order to strengthen the integration and peace building process in ...
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 8

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Functional Analysis of Dopamine Prediction Error Circuits (DopaPredict)

Start date: Dec 1, 2014, End date: Nov 30, 2018,

One of the key goals in neuroscience is to understand how neural activity generates behavior. Electrophysiological recordings have provided great insights into this relationship, but they cannot resolve the contribution of specific neuronal cell types. Moreover, it has been notoriously difficult to move beyond correlation and demonstrate the functional significance of neural firing for specific be ...
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 1

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Metagenomics in Cardiometabolic Diseases (METACARDIS)

Start date: Nov 1, 2012, End date: Oct 31, 2018,

METACARDIS applies a systems medicine multilevel approach to identify biological relationships between gut microbiota, assessed by metagenomics, and host genome expression regulation, which will improve understanding and innovative care of cardiometabolic diseases (CMD) and their comorbidities. CMD comprise metabolic (obesity, diabetes) and heart diseases characterized by a chronic evolution in ag ...
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 18

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The importance of gene and genome duplications for natural and artificial organism populations (DOUBLE-UP)

Start date: Oct 1, 2013, End date: Sep 30, 2018,

"The long-term establishment of ancient organisms that have undergone whole genome duplications has been exceedingly rare. On the other hand, tens of thousands of now-living species are polyploid and contain multiple copies of their genome. The paucity of ancient genome duplications and the existence of so many species that are currently polyploid provide an interesting and fascinating enigma. A q ...
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 1

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Learn, Create and Communicate

Start date: Sep 1, 2015, End date: Aug 31, 2018,

We want to apply for a project that would focus on creativity and culture. The reason for this is our experience that the arts and crafts haven´t been prioritized at schools during the recent years, though the industry and commerce want people entering employment to show powers of innovation, initiative and problem solving. We also felt that many young people today don´t know much about their own ...
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 6

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Stronger Parents - Healthier Communities

Start date: Sep 1, 2016, End date: Aug 31, 2018,

Partnership:Ceutí municipality, Spain. Local authority.Viborg municipality, Denmark. Local authority.ALIAT, Romania. Leading NGO in the addiction field (alcohol and other drugs).Gmina Miejska Ilawa (Poland). Local authority.Iskenderum Youth and Education Association (Turkey). Non-for-profit Association with a wide experience with disadvantged groups (including inmigrants from Syria).Euro-Net (Ital ...
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 7

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Formar&Innovar en Europa

Start date: Sep 1, 2016, End date: Aug 31, 2018,

IES Andrés Benitez was stablished in 1986/87. The school offers all levels of education from compulsory secondary education to Initial and Higher VET courses with specialisations in Commerce, Hairdressing, Esthetics, Electromechanics and welding, Administration and others.We will offer our student, 24 mobilities for a working period of 3 month in England and Italy. The grants will be offer to th ...
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 8

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Molecular mechanisms of neuronal connectivity - the synaptic code for variability and stereotypy (Molmechindividuality)

Start date: Sep 1, 2016, End date: Aug 31, 2018,

Behaviour emerges from an interplay of various brain regions and billions of neurons forming a network. The brain acquires its organization by a series of developmental events. The correct wiring of the brain is crucially important for all brain functions. Nevertheless, the brain is both stereotyped and variable across individuals. Currently only a subset of genes have been identified that shape s ...
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 2

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Capture, dissemination and analysis of multiscale cell migration data for biological and clinical applications (MULTIMOT) (MULTIMOT)

Start date: Aug 1, 2015, End date: Jul 31, 2018,

This proposal addresses the call topic ‘Advancing bioinformatics to meet biomedical and clinical needs’ (PHC-32-2014), with the focus on the standardization, dissemination and meta-analysis of cell migration data. Cell migration is the fundamental process in medically highly relevant topics, including morphogenesis, immune function, wound healing, and cancer metastasis, and the study of cell migra ...
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