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Role of skin dendritic cells in stimulating immune responses initiated in skin (SKIN IMMUNITY)
Start date: Jul 1, 2008, End date: Jun 30, 2010,
Dendritic cells in peripheral immune organs are quiescent sentinels that continuously survey their surroundings by fluid phase uptake and endocytosis. Dendritic cells become activated when pathogen-derived fragments are detected. Engulfed material is now processed into peptides and lipids for incorporation into peptide/MHC or lipid/CD1 complexes, for display to MHC- and CD1-restricted T cells resp ...
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