Search for European Projects

7 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Control of metabolic and inflammatory pathways by nuclear receptors (NR-NET)

Start date: Sep 1, 2013, End date: Aug 31, 2017,

NR-NET is a multidisciplinary consortium, whose activities are directed towards the understanding of the role of Nuclear Receptors (NRs) and coregulators in metaflammatory disease. Metaflammation - metabolic disorders linked to chronic inflammation – is an emerging concept explaining the pathogenesis of a wide-spectrum of diseases. Since several nuclear receptors can directly sense metabolic alter ...
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Molecular Basis of Mammalian Egg-Sperm Interaction (GAMETE RECOGNITION)

Start date: Jan 1, 2011, End date: Dec 31, 2015,

At the dawn of the 21st century, our knowledge of the molecular mechanism of mammalianfertilization remains very limited. Different lines of evidence indicate that initial gamete recognitiondepends on interaction between a few distinct proteins on sperm and ZP3, a major component of theextracellular coat of oocytes, the zona pellucida (ZP). On the other hand, recent findings suggest analternative ...
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Microbes in Allergy and Autoimmunity Related to the Skin (MAARS)

Start date: Apr 1, 2011, End date: Mar 31, 2015,

"Allergy and autoimmunity cause increasing burden to societies worldwide. We study the effect of microbiome on the skin, the forefront barrier to environment, on autoimmunity and allergy, using atopic dermatitis (AD) and psoriasis (PSO) as paradigmatic examples. We have detailed information about the genetic risk factors, as well as the molecular and cellular players in AD and PSO, but we know ver ...
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 10

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The role of Lgr6 as a marker of progenitor cells and cancer-initiating cells in the mammary gland (Lgr6MammarySC)

Start date: Jan 1, 2013, End date: Dec 31, 2014,

The epithelial compartments of the mammary gland are thought to be derived from a tissue stem cell capable of self-renewal and differentiating into all cellular lineages of the mammary gland. Detailed studies of normal and tumorigenic breast stem cells have proven rather cumbersome since these cells are rare and a high degree of purification is needed. Several approaches to isolate mammary stem c ...
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 1

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Broadening the Bioinformatics Infrastructure to unicellular, animal, and plant science (ALLBIO)

Start date: Oct 1, 2011, End date: Sep 30, 2014,

The main aim of AllBio will be the coordination of the partner's activities that are aimed at the extension of a large number of bioinformatics facilities towards applicability in target life science areas beyond human health. Bioinformatics facilities developed for the human health area will be extensively tested on unicellular (incl. bacterial), plant and (farm) animal genomes, and they will be ...
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 11

 FINISHED 

Dissecting the transcriptional mechanisms controlling growth during normal development and cancer (GrowthControl)

Start date: Mar 1, 2009, End date: Feb 28, 2014,

The main scientific questions addressed in this proposal relate to the understanding of molecular mechanisms of growth control and cancer through the combined use of high-throughput technologies and computational biology. We aim to create a systems-level understanding of the cell cycle, and its regulation by physiological growth factors and oncogenes through the use high-throughput biology to iden ...
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 1

 FINISHED 

Understanding Hedgehog signalling in breast cancer and mammary gland stem cells using tissue specific expression of Gli1 the main effector of the Hedgehog pathway (MammaHogLgr)

Start date: Jul 1, 2009, End date: Jun 30, 2011,

Only a subset of tumour cells is capable of giving rise to new tumours. These so called “tumour stem-cells” are functionally similar to adult stem cells and have been identified in tumours of several tissues. Whether transformation of adult stem cells into tumour stem cells is the event leading to the disease is not clear. Alternatively, tumours could arise from the population of committed progeni ...
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