Search for European Projects

8 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Imaging Innate Immunity of Staphylococcal Infections (PSMS-IN-INFLAMMATION)

Start date: Apr 9, 2014, End date: Apr 8, 2017,

"Staphylococcus aureus community-acquired (CA)-MRSA strains are highly virulent and can cause infections in otherwise healthy individuals and are a leading cause of death worldwide. Innate immunity is our primary defense against invading staphylococci. Blood-neutrophils migrate to the site of infection where they, in concert with the complement system, engulf and kill bacteria in a process called ...
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 1

 FINISHED 

Determinants of the switch from R5- to X4-tropic virus in HIV-1 infected individuals (SwitchR5-X4)

Start date: Oct 1, 2013, End date: Dec 15, 2016,

HIV-1 variants utilizing CCR5 (R5) are predominant during early infection, emergence of CXCR4 (X4) strains typically occurs later. Although R5 to X4 switch is strongly correlated with increased rates of disease progression, it remains largely unknown which factors are causing the switch. Based on our preliminary data we postulate that both host (immune activation) and viral factors (target cell af ...
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 1

 FINISHED 

Microvesicle-inspired drug delivery systems (MINDS)

Start date: Dec 1, 2010, End date: Nov 30, 2015,

Current state-of-the-art drug carrier systems deliver new ‘biological drugs’ (like proteins and nucleic acids) poorly to the target site. This is something I daily experience in my research on delivery of small interfering RNA. The in vivo challenges are threefold:• Biological drugs are fragile molecules (subject to degradation and denaturation)• They need to gain access to the target site• They n ...
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 2

 FINISHED 

ATMP GMP Open Access Research Alliance - AGORA (AGORA)

Start date: Sep 1, 2013, End date: Oct 31, 2015,

We propose an academic & industrial partnership to facilitate safe and effective delivery of new advanced therapy medicines within the framework of the relevant EU regulations which our previous FP7 funded project have identified as creating unanticipated barriers to development of this field. Over 80% of advanced therapy medicines (ATMPs) trials in the EU are academic investigator led and sponsor ...
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 8

 FINISHED 

Evolution and Transfer of Antibiotic Resistance (EVOTAR)

Start date: Oct 1, 2011, End date: Sep 30, 2015,

Antibiotics are essential therapeutics in the treatment of bacterial infections. However, the indiscriminate use of antibiotics has led to the emergence of antibiotic resistant bacteria that pose a major threat to human health as options for treating infections by these bacteria have become limited. The evolution, emergence and spread ofantibiotic resistance genes are still only poorly understood ...
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 19

 FINISHED 

Collaborative HIV and Anti-HIV Drug Resistance Network (CHAIN)

Start date: Apr 1, 2009, End date: Mar 31, 2014,

CHAIN is a large scale integrating project aimed to effectively and durably combat new and existing anti-HIV drug resistance in clinical settings, with a special emphasis on Eastern Europe and in heavily affected resource-poor regions in Africa. This will be achieved through our pan-European network of surveillance and basic research activities, the involvement of all main actors in the field of H ...
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 28

 FINISHED 

TARGET MV: Proof of concept study to commercialise a microvesicle-based drug delivery system (TARGETMV)

Start date: May 1, 2012, End date: Apr 30, 2013,

"Biological drugs such as proteins and nucleic acids have poor bioavailability, are subject to degradation and denaturation and need to be delivered to a specific cell type and sometimes even a specific organelle to be active. Therefore, they require a drug delivery system to bring them to the target site. However, the current available drug delivery systems lack efficiency, resulting in poor effi ...
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 1

 FINISHED 

CONtrol of COmmunity-acquired MRSA: Rationale and Development of counteractions (CONCORD)

Start date: Jan 1, 2009, End date: Jun 30, 2012,

"Until recently, methicillin-resistant Staphylococcus aureus (MRSA) were confined to hospitals (HA-MRSA). However, community- and farm-associated MRSA (CA-and FA-MRSA) has developed as an important cause of infections. No strategies exist to combat these MRSA. CONCORD is aimed at explaining the ecological success in the community and the farm environment of CA- and FA-MRSA in contrast to HA-MRSA i ...
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 9