Search for European Projects

9 European Projects Found

Searched on 125080 European Projects

 FINISHED 

GALAXY: Gut-and-liver axis in alcoholic liver fibrosis (GALAXY)

Start date: Jan 1, 2016, End date: Dec 31, 2021,

Alcohol overuse is an important societal challenge with annual healthcare costs of over €22 billion in Europe. Alcohol is the main cause of liver cirrhosis, which is the 5th and 7th most common cause of life years lost in respectively Eastern and Western Europe. Cirrhosis is considered irreversible but its precursor, liver fibrosis, is reversible when detected before disease progression. GALAXY pr ...
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 12

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Elucidating Pathways of Steatohepatitis (EPoS)

Start date: May 1, 2015, End date: Apr 30, 2019,

Strongly associated with the epidemics of obesity and type 2 diabetes mellitus (T2DM) that are testing healthcare systems worldwide, Non-Alcoholic Fatty Liver Disease (NAFLD) is an increasingly common cause of advanced liver disease in the aging population of Europe. NAFLD is a spectrum of hepatic fat accumulation (steatosis); steatosis plus inflammation (non-alcoholic steatohepatitis, NASH); fibr ...
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 13

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Proteomic prediction and Renin angiotensin aldosterone system Inhibition prevention Of early diabetic nephRopathy In TYpe 2 diabetic patients with normoalbuminuria (PRIORITY)

Start date: Jan 1, 2012, End date: Dec 31, 2017,

Patients with diabetes are at risk of developing diabetic nephropathy, which will ultimately result in the requirement for renal replacement therapy and is also associated with high cardiovascular morbidity and mortality. Detection of low concentrations of albuminuria in urine (microalbuminuria) is the current clinical standard for detecting those at significant risk and targeting preventive treat ...
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 21

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Neuroimaging platform for characterisation of metabolic co-morbidities in psychotic disorders (METSY)

Start date: Sep 1, 2013, End date: Aug 31, 2017,

"The theme of this collaborative project is development and application of neuroimaging and bioinformatics tools to study lipid metabolism as a common pathogenic link between psychotic disorders and its metabolic co-morbidities. The overall objective is to identify, prioritize and evaluate multi-modal blood and neuroimaging markers with diagnostic potential for prediction and monitoring of psychot ...
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 13

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Repair of Diabetic Damage by Stromal Cell Administration (REDDSTAR)

Start date: Nov 1, 2012, End date: Oct 31, 2016,

50 million diabetic EU citizens are using approved anti-diabetic agents to control their glycaemia. However, suboptimal glycemic control leads to 6 progressive diabetic complications, namely: nephropathy, retinopathy, cardiomyopathy, neuropathy and foot ulceration. In 2010, 11% of EU adult deaths (634,000) were caused by diabetic complications. These distinct disorders have few effective medicines ...
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 10

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Mechanisms of prevention of type 2 diabetes by lifestyle intervention in subjects with pre-diabetes or at high-risk for progression (DEXLIFE)

Start date: Jan 1, 2012, End date: Dec 31, 2015,

"Type 2 diabetes (T2DM) is preventable by sustained changes in diet and physical exercise. Despite this, modern societies are already approaching 10% population prevalence of diabetes, and another 15% with pre-diabetes. The costs of T2DM are huge, approaching 10% of all health costs. Prevention of diabetes is a priority for national healthcare agencies and for the health insurance industry. Inve ...
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 12

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Development of novel treatment strategies based on knowledge of cellular dysfunction in diabetes (BetaBat)

Start date: Oct 1, 2011, End date: Sep 30, 2015,

A reduction in functional pancreatic beta cell mass is the key feature of type 1 and type 2 diabetes. Beta cell failure is exacerbated in the context of obesity and insulin resistance. Brown adipose tissue (BAT) is a highly metabolic organ, mediating energy dissipation and glucose disposal, thus contributing to maintain energy balance. BAT dysfunction contributes to obesity and impaired glucose me ...
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 12

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Developing an efficient e-infrastructure, standards and data-flow for metabolomics and its interface to biomedical and life science e-infrastructures in Europe and world-wide (COSMOS)

Start date: Oct 1, 2012, End date: Sep 30, 2015,

Metabolomics is an important phenotyping technique for molecular biology and medicine. It assesses the molecular state of an organism or collections of organisms through the comprehensive quantitative and qualitative analysis of all small molecules in cells, tissues, and body fluids. Metabolic processes are at the core of physiology. Consequently, metabolomics is ideally suited as a medical tool t ...
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 16

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Systems biology towards novel chronic kidney disease diagnosis and treatment (SysKID)

Start date: Jan 1, 2010, End date: Dec 31, 2014,

Chronic kidney disease (CKD) affects up to 10% of the population. Besides eventual progression towards end stage renal disease CKD impacts the patient’s quality of life by causing serious comorbidities including cardiovascular complications and bone metabolism disorders. On the everyday clinical level early stage diagnosis and tailored treatment of CKD are still inadequate. In addition, CKD seems ...
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