4 European Projects Found
Searched on 125080 European Projects
FINISHED
Noncoding and Translational Modulation of Gene Expression and Epigenetic Changes (TRANSLATE)
Start date: May 1, 2014, End date: Apr 30, 2019,
"Gene expression studies rely on high throughput techniques, which do not take in account conceptual limits. I will overcome this situation by exploiting two biological facts. First, RNAs that are important in tissue function are a subset of the global mass, but are always associated with the ribosomal machinery and as such should be identified. Second, gene expression is the outcome of dynamic fl ...
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3
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Long non-coding RNAs of tumor infiltrating lymphocytes as novel anti-cancer therapeutic targets (FIGHT-CANCER)
Start date: Apr 1, 2014, End date: Mar 31, 2019,
Although tumor tissues can be infiltrated by T cells specific for tumor antigens, the effector functions of these lymphocytes are generally suppressed by CD4+ regulatory T cells (Tregs). Since tumor infiltrating Tregs can display function heterogeneity, depending on both the tumor type and the inflammatory milieu, only inhibition of the right Treg activity should result in the unleash of an effect ...
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2
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Investigating the topography of nuclear phosphoinositide signalling in relation to chromatin and the genome (nuc-inositide)
Start date: Feb 25, 2015, End date: Feb 24, 2017,
Phosphoinositides (PIs) are an important group of phospholipid messengers that regulate diverse cellular functions. A combination of mono, bis and tris-phosphorylation generates seven different PIs present in various subcellular compartments and importantly found within the nucleus. Nuclear PI levels change in response to diverse stimuli such as differentiation, growth factor receptor activation, ...
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1
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Lymphocyte microRNAs in health and disease: Understanding lymphocyte functions through the identification of microRNA target genes and exploiting serum microRNA signatures to monitor immune responses (I-MIRNOME)
Start date: Jun 1, 2011, End date: May 31, 2016,
Background: CD4+ T lymphocyte subsets orchestrate immune responses in health and disease. Little is known on control of T cell differentiation exerted by microRNA that affect mRNA translation. The identification of microRNA and their targets that regulate differentiation of T cell subsets may provide new therapeutic targets for immune-mediated diseases. Since microRNA are released in exosomes and ...
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