Search for European Projects

16 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Individual Robustness in Development and Cancer (IR-DC)

Start date: Jun 1, 2014, End date: May 31, 2019,

Biological systems are robust to perturbations, with many genetic, stochastic and environmental challenges having no or little phenotypic consequence. However, the extent of this robustness varies across individuals, for example the same mutation or treatment may only affect a subset of individuals. The overall objective of this project is to understand the cellular and molecular mechanisms that ...
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 1

 FINISHED 

Synthetic Cellular Signaling Circuits (SynSignal)

Start date: Nov 1, 2013, End date: Oct 31, 2017,

Cellular signaling systems are crucially important for a broad range of critical health and disease areas and high value industrial applications. Signaling systems are the target for more than half of the medicines marketed by the pharmaceutical industry, and form the main R&D area for the nutrition, flavour and fragrance industries. SynSignal is a multidisciplinary high-tech consortium working in ...
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 10

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Miniature Insect Model for Active Learning (MINIMAL)

Start date: Jan 1, 2014, End date: Dec 31, 2016,

Biology provides the inspiration for a vision of small low-power devices that are able to learn rapidly and autonomously about environmental contingencies, enabling prediction and adaptive anticipatory action. Larval Drosophila have fewer than 10,000 neurons, yet express a variety of complex orientation and learning behaviours, including non-trivial anticipatory actions requiring context-dependent ...
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 4

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PRIMES: Protein interaction machines in oncogenic EGF receptor signalling (PRIMES)

Start date: Dec 1, 2011, End date: Nov 30, 2016,

"PRIMES focuses on the role of protein interactions to assemble dynamic molecular machines that receive and process information to coordinate cellular responses. PRIMES investigates the following: (i) How do protein interactions contribute to the generation of biological specificity in signalling? (ii) How do pathogenetic perturbations affect protein interaction networks? (iii) How can we exploit ...
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 14

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Hearts and limbs: Linking morphometrics with 3D analysis of gene expression patterns (3D Gene Shape)

Start date: May 1, 2013, End date: Aug 9, 2016,

Development of new imaging techniques, such as optical projection tomography (OPT), to visualize gene expression patterns within developing structures in a 3D framework has revolutionized developmental biology research. However, methods to precisely quantify these 3D expression distributions in a systematic manner are still lacking. We are developing a novel approach to combine OPT with Geometric ...
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 1

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Systems neuroscience of Drosophila: from genes to circuits to behaviour (FLIACT)

Start date: Jan 1, 2012, End date: Dec 31, 2015,

Understanding how the brain works represents one of the greatest challenges in modern science. This question embraces mechanisms spanning multiple levels of description, from genes to biochemical pathways, from neurons to circuits, from circuit activities to adaptive behaviours. The goal of the FLiACT programme is to train young researchers in the concepts and techniques necessary to study integra ...
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 11

 FINISHED 

From Data to Models: New Bioinformatics Methods and Tools for Data-Driven Predictive Dynamic Modelling in Biotechnological Applications (BIOPREDYN)

Start date: Oct 1, 2011, End date: Mar 31, 2015,

Currently, biologists are collecting enormous amounts of ‘omics’ data in a vast number of different databases. Predictive, data-driven computational models are needed to understand the complex, multi-scale biological networks underlying these high-throughput datasets. Such models are non-linear and contain many parameters, which are difficult (or impossible) to measure directly. Instead, parameter ...
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 12

 FINISHED 

Quantitative understanding of a living system and its engineering as a cellular organelle (CellDoctor)

Start date: Mar 1, 2009, End date: Feb 28, 2015,

The idea of harnessing living organisms for treating human diseases is not new but, so far, the majority of the living vectors used in human therapy are viruses which have the disadvantage of the limited number of genes and networks that can contain. Bacteria allow the cloning of complex networks and the possibility of making a large plethora of compounds, naturally or through careful redesign. On ...
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 2

 FINISHED 

Proteomics Research Infrastructure Maximising knowledge EXchange and access (XS) (PRIME-XS)

Start date: Feb 1, 2011, End date: Jan 31, 2015,

Genome sequencing initiated a new age in biology. Now, the emphasis is on the biological interpretation of the genome: zooming on the biological functioning of the gene-products, i.e. the proteins, emerging into a filed termed proteomics. Protein levels depend not only on mRNA levels, but also on translational controls & regulated degradation, making the measurement of expression at the protein le ...
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 12

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Engineering zinc fingers to target cancer hub genes (ZINC-HUBS)

Start date: Oct 1, 2008, End date: Sep 30, 2014,

"For the last ten years, protein engineering technologies have been developed to make zinc finger peptides to recognise a wide variety of user-defined DNA sequences. This has enabled the construction of synthetic transcription factors that can upregulate or repress target genes at will. More recently, synthetic zinc fingers have been linked to nucleases to direct double stranded breaks at desired ...
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 4

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Synthetic gene regulatory networks for single-stripe gene expression (SynthStripe)

Start date: Aug 1, 2012, End date: Jul 31, 2014,

A pivotal question in developmental biology is how cellular gene regulatory networks can respond to a signalling molecule in a concentration-dependent manner. This can now be studied using the modern tools of synthetic biology, an emerging research field that applies engineering approaches to biological systems.This project aims to adapt and develop a band-forming model in E. coli. It will explore ...
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 1

 FINISHED 

Euro-BioImaging - Research infrastructure for imaging technologies in biological and biomedical sciences (Euro-BioImaging)

Start date: Dec 1, 2010, End date: May 31, 2014,

Euro-BioImaging brings together imaging technologies stretching from basic biological imaging with advanced light microscopy, in vivo molecular imaging of single cells to animal models up to the clinical and epidemiological level of medical imaging of humans and populations. Euro-BioImaging, in close consultation with its stakeholders, will address the imaging requirements of both biological and m ...
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 44

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In Vivo Imaging of Beta cell Receptors by Applied Nano Technology (VIBRANT)

Start date: Jul 1, 2009, End date: Jun 30, 2013,

Currently, around 30 million people in the enlarged Europe suffer from diabetes, with a prevalence of 7.5% in member states. In recent years the emergence of type 2 diabetes in children and adolescents is a new and serious health challenge to the youth of Europe, their families and society. By 2025, the number of people with diabetes is expected to rise to around 50 million in Europe, thus increas ...
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 11

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Eukaryotic unicellular organism biology – systems biology of the control of cell growth and proliferation (UNICELLSYS)

Start date: Apr 1, 2008, End date: Mar 31, 2013,

The overall objective of UNICELLSYS is a quantitative understanding of fundamental characteristics of eukaryotic unicellular organism biology: how cell growth and proliferation are controlled and coordinated by extracellular and intrinsic stimuli. Achieving an understanding of the principles with which bio-molecular systems function requires integrating quantitative experimentation with simulation ...
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 20

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PROteomics SPECification in Time and Space (PROSPECTS)

Start date: Apr 1, 2008, End date: Mar 31, 2013,

"Proteomics is a major new field in biomedical research, which deals with the large-scale identification and characterization of large groups of proteins, or “proteomes”. These can either be the components of a subcellular organelle or compartment, or even the entire protein complement of whole cells and tissues. Proteomics is essential in the functional annotation of the genome and in future atte ...
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 11

 FINISHED 

Modelling Joint Development: Integrating Biological and Mechanical Influences (MODELLING_JOINT_DEV)

Start date: Nov 1, 2009, End date: Aug 31, 2011,

"Embryonic joint development is a complex process with several distinct stages. The first step occurs in the cartilage anlage, where chondrocytes at the presumptive joint site stop proliferating and become compacted to form what is called the interzone. From the interzone, the synovial cavity develops. Once the cavity has been initiated, the surfaces of the opposing cartilage rudiments undergo gra ...
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