4 European Projects Found
Searched on 125080 European Projects
FINISHED
Metabolic functions of p53 in non-cancer pathologies (METABOp53)
Start date: Feb 1, 2013, End date: Jan 31, 2018,
Extensive study of the p53 protein has resulted in a detailed understanding of its role in tumour suppression, information that is being used to develop small molecule modulators of p53 that are presently under evaluation for cancer therapy. However, it has recently become clear that p53 also plays roles in aspects of human health and disease extending beyond cancer - although most of these are po ...
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1
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Targeting downstream effectors of Wnt signaling in colorectal cancer (ColonCan)
Start date: Nov 1, 2012, End date: Oct 31, 2017,
Colorectal cancer (CRC) is one of the most common cancers of the western world. The underlying initiating mutation for the majority of CRC is within the Adenomatous Polyposis Coli (Apc) gene. The APC protein performs an important role in controlling the levels of Wnt signalling by targeting beta-catenin for degradation. Loss of the APC protein leads to the activation of Wnt signaling target genes ...
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1
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PRIMES: Protein interaction machines in oncogenic EGF receptor signalling (PRIMES)
Start date: Dec 1, 2011, End date: Nov 30, 2016,
"PRIMES focuses on the role of protein interactions to assemble dynamic molecular machines that receive and process information to coordinate cellular responses. PRIMES investigates the following: (i) How do protein interactions contribute to the generation of biological specificity in signalling? (ii) How do pathogenetic perturbations affect protein interaction networks? (iii) How can we exploit ...
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14
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Wnt Signalling in Colorectal Carcinogenesis and Intestinal Homeostasis (Wnt in the Intestine)
Start date: May 1, 2009, End date: Apr 30, 2011,
The intestinal epithelium is a highly self-renewing tissue, which is replenished by multipotent stem cells. Deregulation of normal intestinal homeostasis often results in malignant transformation. Colorectal carcinoma is one of the most common cancers in western world. Inactivating mutations of the Apc (Adenomatous Polyposis Coli) gene is key for colorectal cancer; up to 80% of sporadic colorectal ...
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