6 European Projects Found
Searched on 125080 European Projects
FINISHED
Phylogeography and somatic evolution of cancer tumor cells (PHYLOCANCER)
Start date: Oct 1, 2014, End date: Sep 30, 2019,
"By far, most evolutionary research has focused on the changes that occur in the germline of individuals across generations, within and between species. For different reasons, much less attention has been given to the process of change within the somatic line of a multicellular individual. The formation of cancer tumors due to uncontrolled cell proliferation is one of the most prominent forms of s ...
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4
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RD-CONNECT: An integrated platform connecting registries, biobanks and clinical bioinformatics for rare disease research (RD-CONNECT)
Start date: Nov 1, 2012, End date: Oct 31, 2018,
Despite examples of excellent practice, rare disease (RD) research is still mainly fragmented by data and disease types. Individual efforts have little interoperability and almost no systematic connection between detailed clinical and genetic information, biomaterial availability or research/trial datasets. By developing robust mechanisms and standards for linking and exploiting these data, RD-Con ...
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30
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Chromosome Segregation and Aneuploidy (LONGCHROM)
Start date: Jun 1, 2011, End date: May 31, 2017,
Accurate partitioning of the genetic material during cell division is critical for genetic stability. Defects in chromosome segregation produce aneuploidy, an unequal distribution of chromosomes between daughter cells, which is cause of developmental defects, and one of the cancer hallmarks. To ensure error-free transmission of chromosomes, feedback control systems verify that processes at each st ...
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1
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BBMRI - Large Prospective Cohorts (BBMRI-LPC)
Start date: Feb 1, 2013, End date: Jan 31, 2017,
In recent years, biomedical research has crossed international borders in large, collaborative studies showing the value of multidisciplinarity and scale advantage. This has yielded valuable insights and some led to new and better medicines and treatments for diseases. However, disease-focused studies provide less insight in the real disease onset, the relative disease burden in the population, an ...
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36
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Mechanism of Unconventional Protein Secretion (MUPS)
Start date: Aug 1, 2011, End date: Jul 31, 2016,
Approximately 30% of the human genes encode proteins that enter the Endoplasmic Reticulum (ER) by a hydrophobic sequence called the signal sequence. Most of these proteins are transported to the Golgi apparatus for sorting and subsequent delivery to the endosomes, cell surface, and the extracellular space. There is good understanding of this process of ¿conventional¿ protein secretion. Surprisingl ...
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1
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FINISHED
Airway Disease PRedicting Outcomes through Patient Specific Computational Modelling (AirPROM)
Start date: Mar 1, 2011, End date: Jun 30, 2016,
The airways diseases asthma and chronic obstructive pulmonary disease affect over 400 million people world-wide and cause considerable morbidity and mortality. Airways disease costs the European Union in excess of €56 billion per annum. Current therapies are inadequate and we do not have sufficient tools to predict disease progression or response to current or future therapies. Our consortium, Air ...
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