Search for European Projects

8 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Re-designing zinc finger proteins by swapping alpha-helical domains with foldamer helices (LXWAP)

Start date: Mar 11, 2013, End date: Mar 10, 2015,

"Alpha-helices (aHs) are recurrent structures in proteins, whose folding properties, stability and function have been widely investigated. They often play the key role of recognition elements between proteins, or proteins and nucleic acids. These interactions are generally regulated by the strategic presentation of a few key residues on their surface. The efforts of many groups have been devoted t ...
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 2

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Dynamic Molecular Nanostructures (DYNAMOL)

Start date: Nov 1, 2010, End date: Oct 31, 2014,

The ITN DYNAMOL will establish a powerful new approach for the preparation of nanostructures based on dynamic covalent chemistry. This approach combines the advantages of covalent synthesis (robustness of bonds) with those of non-covalent synthesis (error correction, responsiveness) without any of the disadvantages. It therefore has the potential to provide unique solutions for several important c ...
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 13

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Foldamers against protein-protein interactions (FOLDAPPI)

Start date: Feb 1, 2009, End date: Jan 31, 2014,

The Foldappi proposal aims to investigate the potential of aromatic amide Foldamers to disrupt protein-protein interactions. The scientific goals of the project include: 1. development of synthetic methods to build foldamers with different R-group chemistries 2. development of strategies to target foldamers to protein surfaces 3. measuring in vitro properties of foldamer(s) to assess ADME profile ...
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 5

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An Integrated Peptide and Foldamer Chemistry Approach Towards Pro-apoptotic TRAIL Mimetics (FOLDAPOP)

Start date: May 2, 2011, End date: May 1, 2013,

"Death Receptors (DR), members of the tumour necrosis factor (TNF) receptor family, have come into focus as suitable targets for the selective activation of the cell death (apoptosis) pathway in tumours in vivo without causing toxicity to healthy cells. Current approaches in clinical development for replicating the function of the TNF-related apoptosis inducing ligand (TRAIL) are restricted to rec ...
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 1

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Catalytic Foldamers: Engineering a Second Coordination Sphere Around a Hydrogenase Mimic (Catamers)

Start date: Mar 1, 2011, End date: Feb 28, 2013,

The protein environment that surrounds metalloenzyme active sites imparts a wide range of effects that facilitate catalysis. Supramolecular supports for homogenous catalysis may model a number of these effects. However, the use of dendrimers or polymers to provide directed second coordination sphere effects is limited by their unpredictable/unstable structures. Foldamers, based on aromatic amide u ...
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 1

 FINISHED 

Aromatic Foldamers for Single Molecule Electronics (FOSIMEL)

Start date: Mar 1, 2010, End date: Feb 29, 2012,

"Recent work has demonstrated 1°) the synthetic accessibility of rigid, rod-like, helically folded aromatic amide oligomers of very large size – up to 48 units, over 12 kDa, and 7 nm long; and 2) the ability of short segments of the same oligomers to transport electrons at very fast rates via a super exchange mechanism. This project plans to investigate the potential of such unusual synthetic obje ...
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 1

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AROMATIC FOLDAMERS AS DRUG DELIVERY CARRIERS (HELICAL TRANSPORTERS)

Start date: Apr 1, 2009, End date: Mar 31, 2011,

"The Huc group is a world leading research team in the fields of Biomimetic and Bioorganic Chemistry. One of group’s main contributions is focused on the synthesis, structural elucidation and biological application of aromatic oligoamides. These compounds adopt exceptionally stable folded conformations, helices, stabilised by intramolecular hydrogen bonds and - interactions. The high structural pr ...
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 1

 FINISHED 

FoldAmeRs : a new family of G-QUADruplex ligands (FAR-QUAD)

Start date: Mar 1, 2009, End date: Feb 28, 2011,

"This proposal focuses on the formation of complex between DNA G-quadruplexes and a new family of synthetic ligands, which might be relevant for cancer therapy. The enzymatic acitivity of telomerase is critical to the immortality of most human cancer cell lines. However, telomeric DNA may fold into guanine quadruplex structures which are not competent substrates for telomerase. Therefore, the use ...
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 1