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Direct observation of ligand binding and channel gating on individual ligand-gated ion channels (Fluoropatch)
Start date: Apr 1, 2010, End date: Jun 30, 2013,
Understanding the dynamics of ligand-gated ion channels is essential for understanding synaptic processes and neuronal signal integration (neurotransmitter gated channels) and intracellular signalling (cyclic nucleotide gated channels). Here we will combine single molecule fluorescence detection, with single channel electrophysiology, to detect ligand-binding and follow subsequent channel gating s ...
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