Search for European Projects

24 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Mitochondrial regulation of structural and functional plasticity within adult neurogenic circuits (MITOPLASTICITY)

Start date: Aug 1, 2016, End date: Jul 31, 2021,

A fundamental question in neuroscience is to reveal the energy constrains governing the plasticity of brain circuits. Mitochondrial energy metabolism is increasingly recognized for regulating the activity and integrity of existing synaptic terminals, however it is unclear how changes in mitochondrial function are coupled with the generation of new neurons and the ensuing circuit remodelling, e.g. ...
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 2

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European Network on Anti-Cancer Immuno-Therapy Improvement by modification of CAR and TCR Interactions and Nanoscale Geometry (EN_ACTI2NG)

Start date: Jan 1, 2017, End date: Dec 31, 2020,

The EN-ACTI2NG program (European Network on Anti-Cancer Immuno-Therapy Improvement by modification of CAR and TCR Interactions and Nanoscale Geometry) emanates from the recent clinical evidence that T cells expressing engineered tumor-specific immune receptors can eradicate certain tumors that do not respond to conventional treatment. To obtain T cells with reactivity to a wider array of tumors an ...
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 11

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Controlling Cartilage to Bone Transitions for Improved Treatment of Bone Defects and Osteoarthritis (CarBon)

Start date: Jan 1, 2017, End date: Dec 31, 2020,

A well-functioning locomotor system is essential for human well-being. This is an important consideration in our aging population with the increased associated costs of ensuring high quality of life. Many people suffer from diseases of the locomotor system, such as bone defects or osteoarthritis, for which current treatments are insufficient. To develop new treatments, CarBon includes 6 academic p ...
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 9

 FINISHED 

Antibody-Mediated Therapy of HIV-1 Infection (HIV1ABTHERAPY)

Start date: Jan 1, 2016, End date: Dec 31, 2020,

Antibodies are destined to neutralize pathogens and can prevent and fight infectious diseases. Over the last years, advances in single B cell cloning resulted in the isolation of highly potent and broad HIV-1 neutralizing antibodies (bNAbs) that have been shown to prevent SHIV infection in non-human primates (NHPs). Recently, we have demonstrated that a combination of bNAbs can suppress HIV-1 repl ...
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 2

 FINISHED 

Investigating the impact of meditation training on mental health and wellbeing in the ageing population (MEDIT-AGEING)

Start date: Jan 1, 2016, End date: Dec 31, 2020,

As the number of older people in Europe grows, increasing healthy life years is a priority. Cognitive decline, dementia (e.g. Alzheimer’s disease, AD), sleep disturbances and depression, all related to psychological distress and anxiety, are significant drivers of reduced quality of life in older adults. This project builds on evidence that lifestyle factors and meditation practice have the potent ...
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 12

 FINISHED 

Boost Brittle Bones Before Birth (BOOSTB4)

Start date: Jan 1, 2016, End date: Dec 31, 2020,

...nvasive prenatal diagnosis will be developed and validated. The BOOSTB4 consortium is led by experts in MSC, prenatal therapy and OI at the Karolinska Institutet (KI), which will also lead the international multicentre trial; five additional EU centres of excellence are included. Ethical and regulatory applications are underway to conduct this clinical trial. These are facilitated by the ethical a ...
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 13

 FINISHED 

Breast Cancer Risk after Diagnostic Gene Sequencing (BRIDGES) (BRIDGES)

Start date: Sep 1, 2015, End date: Aug 31, 2020,

Breast cancer affects more than 360,000 women per year in the EU and causes more than 90,000 deaths. Identification of women at high risk of the disease can lead to disease prevention through intensive screening, chemoprevention or prophylactic surgery. Breast cancer risk is determined by a combination of genetic and lifestyle risk factors. The advent of next generation sequencing has opened up th ...
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 20

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Combatting Bacterial Resistance in Europe - Carbapenem Resistance (COMBACTE-CARE)

Start date: Mar 1, 2015, End date: Feb 28, 2020,

...m-negative bacteria (MDR-GNB): the ultimate challenge!Antibiotic resistance is a global public health concern recently elevated to the top three threats identified by the WHO, and subject of numerous national and international government activities. Although focused strategies have beneficially influenced infection rates due to methicillin resistant Staphylococcus aureus (MRSA), infections due to ...
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 23

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Advanced Regenerative and REStorative Therapies to combat corneal BLINDNESS (ARREST BLINDNESS)

Start date: Jan 1, 2016, End date: Dec 31, 2019,

Over 30 million Europeans are blind or visually impaired, leading to reduced quality of life and a tremendous loss of productivity in society. Corneal blindness is the second largest cause of blindness globally and while treatable, millions remain unnecessarily blind due to issues of access to transplantable tissue, lack of standardized treatments, and the lag in translating new regenerative medic ...
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 14

 FINISHED 

Molecular Reclassification to Find Clinically Useful Biomarkers for Systemic Autoimmune Diseases (PRECISESADS)

Start date: Feb 1, 2014, End date: Jan 31, 2019,

We concur to the IMI on “Reclassification of SLE, connective tissue diseases and RA” call by presenting a proposal aimed at using the power of OMICs, and bioinformatics to identify new classifications for diseases known to share common pathophysiological mechanisms. Such knowledge has not been applied to individual patients, depriving them from potential benefits in terms of the use of new therape ...
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 30

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Systems biology for the functional validation of genetic determinants of skeletal diseases (SYBIL)

Start date: Oct 1, 2013, End date: Sep 30, 2018,

...tic determinants of rare and common skeletal diseases and the age related factors contributing to these painful conditions. To achieve this goal SYBIL will gather complementary translational and transnational scientists, systems biologists, disease modellers, leading SMEs and industrialists that will perform in-depth characterisation (complete molecular phenotyping) of pre-clinical models (cellula ...
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 19

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Imaging Voltage Gated Sodium Channels Using Positron Emission Tomography (INSCAPE)

Start date: May 15, 2015, End date: May 14, 2018,

Voltage gated sodium channels (NaVs) are the primary transmembrane proteins underlying fast electrical communication in neurons of the peripheral and central nervous system (PNS and CNS). Being such an integral part of neuronal signaling, they are implicated in a number of severe diseases that have a major impact on human society. However, drugs and established therapies targeting NaVs are rare du ...
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 2

 FINISHED 

European Consortium for the Study of a Topical Treatment of iCRVO to prevent Neovascular Glaucoma (STRONG)

Start date: Oct 1, 2012, End date: Mar 31, 2018,

Neovascular glaucoma (NVG) is a very aggressive and rare type of glaucoma: yet, it contributes disproportionately to blindness from all eye diseases. NVG is also the second most common cause for the removal of the eye-ball across all eye diseases, usually because of intractable pain. The major cause of NVG is Ischaemic Central Retinal Vein Occlusion (CRVO) leading to neovascularisation, obstructio ...
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 9

 FINISHED 

Mitochondrial unfolded protein response and the role in ageing (MITOUPR)

Start date: Jan 1, 2013, End date: Dec 31, 2017,

"Cells use sensor pathways compartmentalized in subcellular organelles to recognize stress conditions, including aberrant protein folding, and in response activate gene expression programs aimed at maintaining cell survival and restoring homeostasis. Fine-tuning of the protein-folding environment in organelles like mitochondria is important for adaptive homeostasis and may participate in developme ...
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 2

 FINISHED 

Integrated European –omics research project for diagnosis and therapy in rare neuromuscular and neurodegenerative diseases (Neuromics)

Start date: Oct 1, 2012, End date: Sep 30, 2017,

Neurodegenerative (ND) and neuromuscular (NM) disease is one of the most frequent classes of rare diseases, affecting life and mobility of 500,000 patients in Europe and millions of their caregivers, family members and employers. This NEUROMICS project brings together the leading research groups in Europe, five highly innovative SMEs and relevant oversea experts using the most sophisticated Omics ...
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 20

 FINISHED 

European Bank for induced pluripotent Stem Cells (EBISC)

Start date: Jan 1, 2014, End date: Dec 31, 2016,

...society. Led by Pfizer Ltd and managed by Roslin Cells, the Consortium comprises 8 active participant iPSC Centres with clinical and patient networks, a global leader in industrial iPSC supply, international experts in iPSC science, biobanking, bioengineering and regenerative medicine, and scholars in law and ethics. The main facility will be at the Babraham Research Campus (Cambridge, UK) and w ...
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 30

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Improving the lives of Parkinson’s Disease patients while reducing side-effects through tailored deep brain stimulation (IMPACT)

Start date: Sep 1, 2012, End date: Aug 31, 2016,

The IMPACT project is about improving the lives of brain diseased patients through a novel approach that leaps beyond currently available Deep Brain Stimulation (DBS) devices and procedures. The initial project focus is on Parkinson’s Disease (PD), but further brain-disease indications will be included in the later phase of the project. The personalized approach that IMPACT brings is essential in ...
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 10

 FINISHED 

Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health (Full4Health)

Start date: Feb 1, 2011, End date: Jan 31, 2016,

Full4Health is a multidisciplinary European collaboration of internationally renowned laboratories investigating the mechanisms of hunger, satiety and feeding behaviour, effects of dietary components and food structure on these processes, and their possible exploitation in addressing obesity, chronic disease and under-nutrition. The proposal integrates investigation of both human volunteers (dieta ...
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 16

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Optimisation of treatment with off-patent antimicrobial agents of ventilator-associated pneumonia (VAP) (MagicBullet)

Start date: Jan 1, 2012, End date: Dec 31, 2015,

Background. Ventilator-associated pneumonia (VAP) is one of the most common and severe hospital-adquired infections, and multidrugresistant gram-negative bacilli (MDR-GNB) constitute the main etiology in many countries. Inappropriate empiric antimicrobial treatment is associated with increased mortality. In this context, the empirical treatment of choice for VAP is unknown. Colistin, and “old” dru ...
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 11

 FINISHED 

European Communication on Research Awareness Needs (ECRAN)

Start date: Sep 1, 2012, End date: Aug 31, 2014,

...re unit supports the preparation and operation of a pan-European infrastructure for clinical trials (ECRIN). Through these instruments, Europe has the capacity to design and conduct independent, multinational clinical trials.The objective of the ECRAN project is to develop tools to communicate key messages to citizens, patients, healthcare professionals, researchers, policymakers and society about ...
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 10

 FINISHED 

A IAPP on the Role of NCAM in Stem Cell Differentiation (STEMCAM)

Start date: Sep 1, 2010, End date: Aug 31, 2014,

The STEMCAM project is a 4-years training and transfer of knowledge program between two distinguished academic groups in stem cell research, two highly innovative SMEs and a company leader in development of media for stem cell research, to foster long-term industry-academy collaboration and partnership in the field of stem cells research and applications. The scientific and industrial aim of STEMC ...
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 6

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Deepening our understanding of quality improvement in Europe (DUQUE)

Start date: Nov 1, 2009, End date: Aug 31, 2013,

Context Hospitals in European countries apply a wide range of quality improvement strategies; however, knowledge on the effectiveness of these strategies is limited. Objectives We propose to study the effectiveness of quality improvement systems in European hospitals. Specific research objectives are: a) to develop a maturity classification model for the assessment of organizational quality improv ...
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 10

 FINISHED 

How does our brain learn to be social? (Social Brain)

Start date: Dec 1, 2009, End date: Nov 30, 2011,

People are per definition social animals. Some even argue that the main reason the human brain is so developed is precisely to support the intricate skills required for successful interactions with others in an increasingly complex social environment. Today, our globalized society indeed requires us to adopt different modes of social interaction in different social contexts, whether this is during ...
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 2

 FINISHED 

European IPF Network: Natural course, Pathomechanisms and Novel Treatment Options in Idiopathic Pulmonary Fibrosis (eurIPFnet)

Start date: Jan 1, 2008, End date: Jun 30, 2011,

...rapeutic targets in these models will be followed by rapid commercial exploitation and early preclinical and early clinical evaluation. Ultimately, we wish to establish a unique, sustainable and internationally unrivalled European infrastructure for investigation and treatment of IPF. Our mission statement is straight-forward and clear: “Fighting for improved survival in Idiopathic Pulmonary Fibro ...
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