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DevelopAKUre is a proposal to fund the clinical development of an orphan designated drug, nitisinone, for the treatment of a rare Mendelian disease, Alkaptonuria (AKU). AKU is a genetic deficiency of homogentisic acid dioxygenase, causing high levels of homogentisic acid (HGA). Oxidation of HGA to pigment polymer, termed ochronosis, alters connective tissues. This leads to multisystemic damage dom ...

Europe has a fascinating history and various historic sites, which demonstrate imperial glory and power, which attract tourists and students of different disciplines like architecture, building culture, but also cause serious concerns. In Austria, a vast number of buildings is considered of historic value, namely ------. On one hand each building causes costs for maintenance, on other hand they ne ...