The objective of this proposal is to improve analytical performance of Desorption Electrospray Ionization (DESI) coupled to a high resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometer (FT-ICR-MS) and gain more insight into the DESI mechanism and underlying processes. DESI is a novel ionization method, that combines features of electrospray ionization (ESI) with those of the famil ...