Search for European Projects

9 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Heart OMics in AGEing (HOMAGE)

Start date: Feb 1, 2013, End date: Jan 31, 2019,

As more people survive into old age, the prevalence of heart failure (HF), one of the most common and debilitating diseases in older people, will rise still further. Delaying or preventing HF will have great benefit to those at personal risk, their families, society and the economy. HOMAGE aims to provide a biomarker (BM) approach that will a) help identify i. patients at high risk of developing ...
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 22

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Systems Biology to Identify Molecular Targets for Vascular Disease Treatment (SYSVASC)

Start date: Feb 1, 2014, End date: Jan 31, 2018,

Asymptomatic vascular damage accumulates for years before patients are identified and subjected to therapeutic measures. The limited knowledge on early vascular disease pathophysiology is reflected in the lack of therapeutic options. SysVasc aims to overcome this limitation by mounting a comprehensive systems medicine approach to elucidate pathological mechanisms, which will yield molecular target ...
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 19

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Automation of Flow Cytometric Analysis for Quality-Assured Follow-up Assessment to Guide Curative Therapy for Acute Lymphoblastic Leukaemia in Children (AutoFlow)

Start date: Feb 1, 2014, End date: Jan 31, 2018,

Acute Lymphoblastic Leukaemia is the most frequent leukaemia entity in children and adolescents. Despite continued progress and refinement of therapeutic approaches, disease relapse due to insufficient extinction of leukaemic blasts still remains the number one cause of treatment failure. About 15-20% of paediatric patients with the disease still suffer from relapse. Flow cytometry (FCM) is one of ...
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 5

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Personalized diagnostics and treatment of high risk coronary artery disease patients (RISKYCAD)

Start date: Nov 1, 2012, End date: Oct 31, 2017,

Although the accurate diagnosis and prevention of coronary artery disease (CAD), acute myocardial infarction (AMI) and death is a major public health issue, risk stratification for CAD with current diagnostic tools is not properly supporting clinical decision making. RiskyCAD’s overall goal is to identify novel biomarkers for asymptomatic patients in high risk of major coronary events, and develop ...
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 12

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Optimizing Exercise Training in Prevention and Treatment of Diastolic Heart Failure (OptimEx)

Start date: Oct 1, 2013, End date: Mar 31, 2017,

More than 14 million Europeans suffer from heart failure (HF), of which more than 50 % have HF with preserved left ventricular (LV) ejection fraction (EF) (HFPEF, “diastolic heart failure”). HFPEF is the only cardiovascular disease with increasing prevalence and incidence, affecting 10-20% of the elderly and contributing substantially to hospitalizations of elderly HF patients. Currently, no medic ...
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 9

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The Function of the RBP4 Receptor Stra6 during Retinol Saturase Regulated Adipocyte Differentiation (Stra6)

Start date: Sep 1, 2011, End date: Aug 30, 2016,

Obesity-related metabolic disorders such as type 2 diabetes reach epidemic proportions in most industrialized countries. Retinol binding protein 4 (RBP4), the only specific serum protein for the delivery of retinol to tissues, is increased in obesity and contributes to the development of insulin resistance and type 2 diabetes. The protein encoding stimulated by retinoic acid gene 6 (stra6) was rec ...
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 1

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The multisensory mind: From neural mechanisms to cognition (Multisensory-Mind)

Start date: Apr 1, 2011, End date: Mar 31, 2016,

Why does food lose its taste when your nose is stuffed up? Why are we better in hearing speech when we see a speaker’s lip movements? These are questions of interest in the emerging field of multisensory integration (MI). Although the scientific study of MI on the behavioral level has existed since psychology became an experimental discipline, little is known about the precise mechanisms underlyin ...
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 1

 FINISHED 

Vesicular glutamate transporters as molecular regulators of neural communication (SYNVGLUT)

Start date: Apr 1, 2010, End date: Mar 31, 2015,

This proposal describes experiments aimed at defining the multiple roles of vesicular glutamate transporters (VGLUTs) in central synapses. Classically, VGLUTs transport glutamate from the cytoplasm into synaptic vesicles. Deletion of these genes disrupts synaptic glutamate release and their expression suffices to determine neurons as glutamatergic. We recently discovered that VGLUTs control additi ...
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 1

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Towards Understanding the Structure and Dynamics of Receptor Proteins (TUDOR)

Start date: Apr 1, 2010, End date: Mar 31, 2015,

"Upon binding an agonist, the seven transmembrane (TM) helical bundle of a G-protein coupled receptor (GPCR) undergoes conformational changes that catalyze nucleotide exchange within bound G proteins. In rhodopsin, the agonist arises from light-induced isomerization of the retinal ligand, but an active conformation (Ops*) can also be adopted by the opsin apoprotein. We recently solved the structur ...
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