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4 European Projects Found

Searched on 125080 European Projects

 FINISHED 

EURO EWING Consortium – International Clinical Trials to Improve Survival from Ewing Sarcoma (EEC)

Start date: Oct 1, 2013, End date: Sep 30, 2018,

Ewing Sarcomas (ES) are fatal, rare bone cancers particularly affecting young people. About 60% of patients achieve long term survival with current treatment but there has been no improvement in this proportion for 25 years. Treatment is unsuccessful because chemotherapy fails to prevent the development of, or to effectively treat established, metastases. In addition, of the 600 new cases of ES o ...
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 21

 FINISHED 

First in Man Novel Anticancer Therapeutic based on Dependence Receptors Concept (HERMIONE-2MAN)

Start date: Sep 1, 2013, End date: Aug 31, 2016,

It is usually assumed that transmembrane receptors are inactive unless bound by their respective ligand. Against this dogma, the CLB proposed that some receptors may also be active in the absence of ligand and in this case trigger cell death. These receptors were called dependence receptors (DR) as their expression at the cell surface leads the cell to be dependent for its survival on ligand avail ...
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 5

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Developing and validating disease management evaluation methods for European health care systems (DISMEVAL)

Start date: Jan 1, 2009, End date: Dec 31, 2011,

Chronic health conditions that impose a heavy burden on society and account for a large share of health care costs. Better prevention and management could potentially decrease costs and improve quality of care and health outcomes. An important means of accomplishing these goals is through the use of disease management (DM) interventions that educate patients about prevention and health management ...
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 10

 FINISHED 

Investigating a novel role of Notch3 as a dependence receptor and its relevance in vivo (NOTCH3DR)

Start date: Jul 1, 2010, End date: Aug 31, 2011,

"Cell survival depends on the integration of numerous signals provided by the extracellular environment. Activation of signal transduction by transmembrane receptors is assumed to occur following interaction with a specific ligand. However, some receptors, called dependence receptors (DRs) have been shown to mediate a signal in the absence of ligand. These receptors share the ability to mediate tw ...
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