5 European Projects Found
Searched on 125080 European Projects
FINISHED
Biological Membranes in Action: A Unified Approach to Complexation, Scaffolding and Active Transport (MEMBRANESACT)
Start date: Oct 1, 2013, End date: Sep 30, 2019,
In recent breakthrough publications, the effect of fluctuations on the affinity of membrane-confined molecules has been evaluated, and a quantitative model for the time evolution of small adhesion domains has been developed under my leadership. Now I propose to bring my research to a new level by tackling the problem of active and passive organisation of proteins into macromolecular structures on ...
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2
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Development of Stem Cell Based Therapy for Thymic Regeneration (THYMISTEM)
Start date: Oct 1, 2013, End date: Sep 30, 2017,
Reconstitution of immune system function in immunocompromised patients depends on the presence of a functional thymus, and specifically, on the diverse array of epithelial cells within the thymic stroma. The thymus is the first organ to degenerate in normal healthy individuals, and is also sensitive to cytotoxic interventions. Therefore lack of thymic function presents a serious problem for many p ...
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7
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Learning from Massive, Incompletely annotated, and Structured Data (MAESTRA)
Start date: Feb 1, 2014, End date: Jan 31, 2017,
The need for machine learning (ML) and data mining (DM) is ever growing due to the increased pervasiveness of data analysis tasks in almost every area of life, including business, science and technology. Not only is the pervasiveness of data analysis tasks increasing, but so is their complexity. We are increasingly often facing predictive modelling tasks involving one or several of the following c ...
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5
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Foundational Research on MULTIlevel comPLEX networks and systems (MULTIPLEX)
Start date: Nov 1, 2012, End date: Oct 31, 2016,
Future advancements in ICT domain are closely linked to the understanding about how multi-level complex systems function. Indeed, multi-level dependencies may amplify cascade failures or make more sudden the collapse of the entire system. Recent large-scale blackouts resulting from cascades in the power-grid coupled to the control communication system witness this point very clearly. A better unde ...
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24
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FINISHED
Presenilin 2 - a protector against Alzheimer's disease (BrainProtect)
Start date: Oct 1, 2014, End date: Sep 30, 2016,
Accumulation of neurotoxic amyloid beta peptides (Ab) in the brain is considered to be the central event in the pathogenesis of Alzheimer’s disease (AD). Ab is released from the beta-amyloid precursor protein (APP) during specialised processing events. This proposal aims to examine presenilin 2 (PS2) protein-mediated molecular and cellular events that are protective against Ab accumulation and AD ...
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