Search for European Projects

24 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Professional cross-priming for ovary and prostate cancer (PROCROP)

Start date: Sep 1, 2015, End date: Aug 31, 2020,

...mphocytes endowed with the ability to seek and destroy tumour cells (such immune mechanism is termed crosspriming). This unique opportunity for superior DCs for immunotherapy comes from the fact that Miltenyi, a successful European biotech company, has the necessary proprietary reagents (anti-BDCA-3 monoclonal antibody and immunomagnetic selection technology), as well as the expertise to clinicall ...
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 8

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Silicon Nitride Photonic Integrated Circuit Pilot line for Life Science Applications in the Visible Range (PIX4LIFE)

Start date: Jan 1, 2016, End date: Dec 31, 2019,

Photonics is essential in today’s life science technology. PIX4life will mature a state of the art silicon nitride (SiN) photonics pilot line for life science applications in the visible range and pave the way to make it accessible as an enabler for product development by a broad range of industrial customers. We aim at 1) establishing a validated CMOS compatible SiN technology platform in the vis ...
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 16

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Chimeric Antigen Receptors (CARs) for Advanced Therapies (CARAT)

Start date: Jan 1, 2016, End date: Dec 31, 2019,

Chimeric antigen receptors (CARs) are artificial surface receptors that can be introduced into somatic cells by genetic engineering and that act as recognition molecules like antibodies or T-cell receptors. In this respect, CARs are increasingly used for cellular therapy to redirect T-cells specifically towards killing of cancer cells. Recent success stories of cancer therapy with CAR modified T-c ...
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 9

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DevelopIng Genetic medicines for Severe Combined Immunodeficiency (SCID) (SCIDNET)

Start date: Jan 1, 2016, End date: Dec 31, 2019,

Severe combined immunodeficiency (SCID) is a devastating rare disorder of immune system development. Affected infants are born without functional immune systems and die within the first year of life unless effective treatment is given. Treatment options are limited to allogeneic haematopoietic stem cell transplantation and autologous stem cell gene therapy. Over the last 15 years, gene therapy for ...
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 13

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Upscaling human insulin-producing beta cell production by efficient differentiation and expansion of endoderm progenitors (HumEn)

Start date: Jan 1, 2014, End date: Dec 31, 2017,

Despite progress in producing beta cells from human pluripotent stem cells (hPSCs) in recent years, full differentiation cannot be obtained in vitro. The HumEn project hypothesises that a fundamental understanding of the coupling between endodermal progenitor expansion and differentiation is relevant for elucidating how to a) generate glucose-responsive beta cells from hPSCs in vitro, and b) gener ...
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 9

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Adoptive engineered T cell Trials to Achieve Cancer Killing (ATTACK)

Start date: Dec 1, 2012, End date: Nov 30, 2017,

The aim of this research is to exploit technology for nucleic acid delivery through the clinical testing of adoptive engineered T cells to treat cancer. Recent innovative developments in cancer gene-immunotherapy have led to very encouraging early clinical results. However, the use of engineered T cells is a challenging and complex field with further development and more proof-of-principle trials ...
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 16

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Stem-cell based therapy for kidney repair (STELLAR)

Start date: Nov 1, 2012, End date: Oct 31, 2017,

Chronic kidney disease (CKD) affects 8% of the European population and ultimately results in renal failure due to progressive fibrosis. CDK carries a high mortality risk and the number of affected people rises, increasing the demand on renal replacement therapies while the number of available donor organs stays stable.The STELLAR consortium proposes to develop an alternative to renal replacement ...
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 15

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A Unified Approach to Evaluating Cellular Immunotherapy in Solid Organ Transplantation (THE ONE STUDY)

Start date: Nov 1, 2010, End date: Oct 31, 2017,

Preventing immunological rejection of transplanted organs without the need for long-term use of pharmacological immunosuppression is a primary objective in transplantation medicine. Reducing the need for immunosuppression would dramatically improve the outcome for transplant recipients and reduce health costs for society. The means to achieve this goal has not been realised with pharmacological or ...
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 16

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European stem cell consortium for neural cell replacement, reprogramming and functional brain repair (Neurostemcellrepair)

Start date: Oct 1, 2013, End date: Sep 30, 2017,

Neurostemcellrepair aims at taking human stem cells through the final steps toward clinical application in cell replacement therapy for neurological disorders. PD will be taken as the prototypical disease because stem cell therapy is now close to clinical translation. Moreover, we will tackle next generation issues pertaining to stem cells at a basic level and develop new approaches and novel cell ...
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 13

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The impact of chromosomal instability on health: Molecular causes and consequences of aneuploidy (PLOIDYNET)

Start date: Oct 1, 2013, End date: Sep 30, 2017,

Aneuploidy, an abnormal number of chromosomes, is a hallmark of cancer cells, affecting the majority of all human tumours. Aneuploidy arises when errors occur during mitosis, as the duplicated chromosomes are distributed between the two new daughter cells. Paradoxically, aneuploidy appears to have detrimental consequences for the physiology of untransformed cells in vitro, inhibiting rather than s ...
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 14

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Initial Training Network for Neurogical disorders orchestrated by cytoKines (NEUROKINE)

Start date: Jan 1, 2013, End date: May 31, 2017,

Neuroinflammatory disease, in particular multiple sclerosis affects more than 700.000 people within Europe alone. European countries are at the forefront of neuroimmunological research and students in medicine and biology are greatly attracted by the field. Neuroimmunology research further impacts our understanding of the ethiopathology of other CNS-disorders including Alzheimer’s Dementia and Mor ...
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 13

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Natural Killer Cell-Based Anti-Cancer Immunotherapies: Research training in molecular medicine and biotechnology business (NATURIMMUN)

Start date: Oct 1, 2012, End date: Sep 30, 2016,

"In the research part we will deal with the basic principles of the innate immune defense used to control tumors and viral infections with a focus on NK and NK/T cells, including analysis of NK receptor genomics/epigenetics, gene polymorphisms/disease linkage, differentiation of hitherto unrecognized NK cell subpopulations and novel ligands for NK receptors exposed by tumor and/or virally infected ...
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 12

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MARie CuRIe AGEing Network (MARRIAGE)

Start date: Oct 1, 2012, End date: Sep 30, 2016,

"One of achievements of developed societies has been the remarkable extension of human lifespan. In the upcoming decades the number of Europeans with advanced age will increase dramatically. It is evident that age-associated diseases will become much more prevalent. This poses challenges for society but also opportunities for commercial enterprises that develop strategies to combat deleterious con ...
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 11

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Improving HSCT By Validation Of Biomarkers & Development Of Novel Cellular Therapies (CELLEUROPE)

Start date: Oct 1, 2012, End date: Sep 30, 2016,

Novel transplant regimens are currently being developed to improve beneficial GvL effects and reduce GvHD and infections via several new forms of cellular therapies. This newly emerging supra-disciplinary field of cellular therapy and regenerative medicine is also being used to improve outcomes in autoimmune disease (such as Rheumatoid Arthritis) and cancers. The goal of this research programme is ...
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 13

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Advanced Cell-based Therapies for the treatment of Primary ImmunoDeficiency (CELL-PID)

Start date: Nov 1, 2010, End date: Apr 30, 2016,

Primary immune deficiencies (PID) are inherited disorders of the adaptive and innate immune system marked by severe infections, autoimmunity and high risk of cancer. Treatment entails hematopoietic stem cell (HSC) transplantation from allogeneic donors, however in the absence of an HLA compatible donor, HSCT outcome is limited by delayed or suboptimal reconstitution and complications. SCID-X1 and ...
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 20

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Stromal Cell- Immune Cell Interactions in Health and Disease (STROMA)

Start date: Jan 1, 2012, End date: Dec 31, 2015,

STROMA is an Initial Training Network promoting the study of stromal cell – immune system interactions during stroma development and function in health and disease. In STROMA we have bought together world leading experts from academia and industry in Europe to address the key scientific questions in this emerging field. STROMA will promote the training of three Experienced Researchers (ER) and s ...
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 12

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Dopaminergic Neurons for Cell Therapy in Parkinson's Disease (DOPANEW)

Start date: Dec 1, 2011, End date: Nov 30, 2015,

Replacement of lost dopaminergic neurons by neural transplantation with embryonic nigral tissue is a most promising approach to the treatment of Parkinson’s disease. However, the limited availability of human embryonic dopaminergic neurons makes the search for alternative sources of transplantable neurons a priority. Based on an existing collaboration, a French academic research group with experti ...
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 2

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Recruitment and activation of brown adipocytes as preventive and curative therapy for type 2 diabetes (DIABAT)

Start date: Oct 1, 2011, End date: Sep 30, 2015,

"The DIABAT project will employ knowledge of the function, dysfunction and physiological regulation of brown adipocytes to develop innovative therapeutic and preventive strategies for type 2 diabetes. Brown adipose tissue (BAT) is currently a worldwide recognized target to combat obesity and diabetes due to last years re-discovery of functional BAT in adult humans by several of the members of the ...
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 22

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EUROCANCER STEMCELL TRAINING NETWORK (EuroCSCTraining)

Start date: Jan 1, 2011, End date: Dec 31, 2014,

The recent identification of tumor initiating (TIC) or cancer stem cells (CSC) has opened a new area of research for scientists interested in cancer. Understanding the biology of cancer stem cells has already unraveled pathways and potential targets. However, accumulating data has underscored the complexity of the CSC research area and prompts hence the need for well-structured networks to provid ...
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 11

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Optimization of stem cell therapy for clinical trials of degenerative skin and muscle diseases (OptiStem)

Start date: Jan 1, 2009, End date: Dec 31, 2013,

This proposal aims to develop and implement efficacy of clinical trials with adult, tissue stem cells for degenerative diseases of epithelia and skeletal muscle. Extraordinary progress in the understanding of several key features of stem cells has been rapidly translated into novel cell therapy protocols that have yielded positive results in pre-clinical models of genetic and acquired diseases and ...
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 20

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Advanced Teaching and TRaining for Adoptive Cell Therapy (ATTRACT)

Start date: Oct 1, 2009, End date: Sep 30, 2013,

Considerable resources are devoted to fighting cancer throughout Europe, yet these efforts are not producing the results that health practitioners and citizens might expect. This is partly due to the fragmentation and duplication of research efforts within Member states and the lack of co-ordination at European level. However it can also be attributed to the need to retain and most importantly dev ...
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 16

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Angiogenesis-inducing Bioactive and Bioresponsive Scaffolds in Tissue Enginering (AngioScaff)

Start date: Dec 1, 2008, End date: Nov 30, 2012,

Angiogenesis underlies almost all biological processes of morphogenesis, including those in tissue repair and regeneration. Physiological angiogenesis is controlled by a complex interplay between cells and their environment: the extracellular matrix (ECM) provides signaling via numerous ECM adhesion molecules and growth factors bound to ECM polysaccharide components; and cells locally degrade and ...
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 33

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Axonal regeneration, plasticity & stem cells (AXREGEN)

Start date: Sep 1, 2008, End date: Aug 31, 2012,

This is a multi-disciplinary training programme focussed on the experimental and clinical problems associated with axonal damage and repair in the central nervous system. This is a central feature of a wide variety of disorders of the CNS. Future advances in this area depend on training a cohort of young researches with multiple skills. The programme encompasses ten academic and two commercial org ...
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 13

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Set up and comparison of multiple stem cell approaches for kidney repair (STAR-T REK)

Start date: Nov 1, 2008, End date: Oct 31, 2011,

"With the increasing rate of end-stage renal failure and limited alternatives for its treatment, potential regenerative approaches for kidney damages are urgently needed. Because of the complexity of the organ, the development of stem cell therapies for kidney is still in its infancy. Identifying which cell types are capable of beneficial effects is the critical step required to realize the potent ...
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 11