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Overcoming the barriers that the cell envelope and efflux pumps provide to Gram-negative bacteria is a major bottleneck in the discovery and development of new antibiotics. To respond to this Call we are extending our current network on antibiotic translocation and propose an ambitious project ranging from identification of novel resistance mechanisms in clinical bacterial isolates to crystallizat ...

Europeans have low compliance to dietary guidelines and recommendations, resulting in poor health and unhealthy ageing. Public health campaigns hardly improve this compliance. A new paradigm emerges of personal dietary advice based on personal preference, health status and assessment, and motivational goals. A number of FP6 and PF7 project have developed concepts, tools and infrastructures with a ...