6 European Projects Found
Searched on 125080 European Projects
FINISHED
REwiring the nucleus TowaRds plant ImmuNity (RETRaIN)
Start date: Jan 1, 2013, End date: Dec 31, 2017,
Plant pathogenic microbes cause significant economic damage to global food crop production systems. Pathogens are specialised microbes that manipulate the host defense circuitry to suppress immunity and promote virulence. Interestingly, many of the processes that determine immunity or susceptible interactions, take place in the host nucleus. With the identification of vast repertoires of (nuclear) ...
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Reporter models for the Evaluation of Diseases involving OXidative stress (REDOX)
Start date: Mar 1, 2012, End date: Feb 28, 2017,
"Perturbations in cellular redox status are implicated in many human diseases, yet there is an extreme lack of knowledge about the effects of oxidative stress in vivo, mainly due to difficulties in measuring reactive oxygen species (ROS) in vivo and the absence of experimental models. REDOX will use novel transgenic technologies to develop mouse models that report on ROS in vivo, allowing spatio- ...
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Colonic Disease Investigation by Robotic Hydro-colonoscopy (CODIR)
Start date: Aug 1, 2011, End date: Jul 31, 2016,
"CODIR proposes a new configuration of fundamental and applied biomedical and engineering multidisciplinary research to explore and characterise colon behavior necessary for the project and wider objectives. Scope and focus is on novel robotic hydro-colonoscopy (RHC), which stems from two considerations: (i) replacement of the flexible colonosocope with a patient-friendly system for inspection of ...
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2
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Tissue engineering to evaluate novel treatments for skin cancer and genetic disease (TREATSKIN)
Start date: May 1, 2010, End date: Apr 30, 2015,
As our understanding of disease translates from basic science to clinical application there is a need for robust preclinical models to test interventions and therapies, which mirror the clinical situation and likely outcomes. This will assist key stage decision making before costly clinical trials are commenced. Skin diseases represent a significant health burden. Non-melanoma skin cancers includi ...
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Regulation and Function of Cullin-Ring E3 ubiquitin ligases and the Nedd8 ubiquitin-like protein modification system (NEDD8ANDCRLLIGASES)
Start date: Nov 1, 2009, End date: Oct 31, 2014,
Cullin-RING E3 ubiquitin ligases (CRLs) are multi-subunit enzyme complexes that catalyze isopeptide bond formation between the C-terminal glycine residue of the small protein ubiquitin and lysine residues of substrate proteins (ubiquitination). Multiple rounds of ubiquitination lead to the formation of ubiquitin chains, which are recognized by the 26S-proteasome, a protease that degrades the subst ...
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From Mutations to Metastases: Multiscale Mathematical Modelling of Cancer Growth and Spread (M5CGS)
Start date: Sep 1, 2009, End date: Aug 31, 2014,
"Cancer is one of the major causes of death in the world (particularly the developed world), with around 11 million people diagnosed and around 7 million people dying each year. The World Health Organisation predicts that current trends show around 9 million will die in 2015, with the number rising to 11.5 million in 2030. Cancer growth (viz. solid tumour growth) is a complicated phenomenon inv ...
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