4 European Projects Found
Searched on 125080 European Projects
FINISHED
Systems biology of liver cancer: an integrative genomic-epigenomic approach (MODHEP)
Start date: Jan 1, 2011, End date: Jun 30, 2016,
"Cancer is a complex disease involving multiple genetic and epigenetic events occurring, and influencing each other, over a long period of time. Understanding cancer, and ultimately developing effective targeted therapies, will therefore require that mutations and epigenetic alterations be systematically investigated during the multiple stages of disease development, from identifiable pre-neoplast ...
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18
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Determining the roles of the nuclear periphery in mammalian genome function (FunctionalEdge)
Start date: Mar 1, 2010, End date: Feb 29, 2016,
DNA sequence and epigenetic chromatin maps are important in understanding how genomes are regulated. However, these maps are linear and do not account for the three-dimensional context within which the genome functions in the cell. The spatial organisation of the genome in the nucleus is not random and is conserved in evolution, implying that it is under functional selection. This proposal aims to ...
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2
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“The International Data Coordination Centre” (I-DCC)
Start date: Jan 1, 2009, End date: Sep 30, 2013,
"The I-DCC coordination and support project responds to the topic defined by HEALTH-2007-2.1.2-6 “International activities in large-scale data gathering and systems biology”. I-DCC integrates European skills, efforts, resources, and infrastructure in an international collaborative programme to establish a European Data Coordination Centre for mouse genetic resources. Large-scale mouse mutagenesis ...
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10
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Genomic Regulatory Systems of Human X-linked neurological diseases (NeuroXsys)
Start date: Jun 1, 2009, End date: Nov 30, 2012,
NeuroXsys will generate regulatory maps and models of the human X chromosome based on evolutionary conservation, with special attention to genes and regions implicated in X-linked neurological diseases. Vertebrate chromosomes are subdivided into domains of genomic regulatory blocks (GRBs) and NeuroXsys aims to map all GRBs on the X chromosome through bioinformatic approaches, extract gene regulato ...
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