Search for European Projects

20 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Targeting SYNthetic lethal interactions for new cancer treatments TRAINing network (SYNTRAIN)

Start date: Sep 1, 2016, End date: Aug 31, 2020,

Breast and ovarian cancer constitute serious health challenges in the EU. To identify new improved cancer therapeutic approaches, we will pursue a multi-facetted synthetic lethal approach, which takes advantage of the inherent genetic instability of cancer cells. Most mutations acquired by cancer cells do not cause lethality, but the very same mutations may cause cell death when a second gene in a ...
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 10

 FINISHED 

Lysosomes as targets for cancer therapy (LYSOSOME)

Start date: Feb 1, 2014, End date: Jan 31, 2019,

"Knowing that the lysosomes contain a powerful cocktail of hydrolases capable of digesting cells and entire tissues, it is obvious that the maintenance of lysosomal membrane integrity is of utmost importance for all cells, and especially for cancer cells with dramatically increased lysosomal activity. Yet, the mechanisms that regulate lysosomal membrane stability have remained obscure, largely due ...
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 1

 FINISHED 

Exploiting MELanoma disease comPLEXity to address European research training needs in translational cancer systems biology and cancer systems medicine (MEL-PLEX)

Start date: Dec 1, 2014, End date: Nov 30, 2018,

Novel treatment options and associated personalised, patient-tailored therapies need to be explored and developed for highly heterogeneous and chemotherapy resistant cancers, such as malignant melanoma. This can only be achieved by industry-academia collaborations in newly emerging, innovative research disciplines such as translational cancer systems biology and systems medicine. These disciplines ...
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 11

 FINISHED 

Comparing health services interventions for the prevention of HPV-related cancer (COHEAHR)

Start date: Nov 1, 2013, End date: Oct 31, 2018,

Important progress has been made in the field of HPV-disease prevention with the development and implementation of HPV vaccines and HPV DNA screening. In the CoheaHr project, the (cost-) effectiveness of different European preventive strategies will be compared. The goal is to build a reliable and comparable evidence base on the (cost-) effectiveness of these policies implemented under country-spe ...
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 13

 FINISHED 

PanCare Studies in Fertility and Ototoxicity to Improve Quality of Life after Cancer during Childhood, Adolescence and Young Adulthood (PANCARELIFE)

Start date: Nov 1, 2013, End date: Oct 31, 2018,

Survival rates after childhood cancer now reach nearly 80% in developed European countries as a result of more effective therapies and better supportive care, leading to a steady increase in the number of survivors in the population. However, the treatments that have improved survival are harsh and cause serious side-effects that can greatly impact survivors’ quality of life in the long term. The ...
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 19

 FINISHED 

Health consequences of noise exposure from road traffic (QUIET)

Start date: Mar 1, 2012, End date: Feb 28, 2017,

There is growing public concern about adverse effects of traffic noise on health, as research has found that traffic noise increases the risk for cardiovascular diseases. Noise is thought to act as a stressor and disturbs sleep. Though this potentially could increase the risk for other major diseases, noise effects on other than the cardiovascular diseases are virtually unexplored.The main objecti ...
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 2

 FINISHED 

Epidemiological study to quantify risks for paediatric computerized tomography and to optimise doses (EPI-CT)

Start date: Feb 1, 2011, End date: Jan 31, 2017,

Diagnostic radiation represents an indispensable, sometimes life-saving, tool in modern medicine. However, the growing use of computerized tomography (CT) is a topic of concern in radiological protection, especially for children and adolescents. Children are generally more sensitive to the carcinogenic effects of ionizing radiation than adults. In addition, they have a longer life-span to express ...
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 22

 FINISHED 

A European Platform for Translational Cancer Research (EUROCANPLATFORM)

Start date: Jan 1, 2011, End date: Dec 31, 2016,

Europe has a number of advantages as regards developing translational cancer research, yet there is no clear European strategy to meet the increasing burden posed by cancer. The FP6 Eurocan+Plus project analysed the barriers underlying the increasing fragmentation of cancer research and stressed the need to improve collaboration between basic/preclinical and comprehensive cancer centres (CCCs), in ...
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 29

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Epidemiological Studies of Exposed Southern Urals Populations (SOLO)

Start date: Mar 1, 2010, End date: Feb 28, 2015,

This project aims to improve estimates of the risks of long-term health effects associated with protracted external and internal radiation exposures, through further studies of exposed populations in the Southern Urals (Russian Federation). Specific objectives of the project are as follows: 1. To develop improved modules for estimating external doses to exposed cohorts in the Southern Urals. It is ...
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 13

 FINISHED 

Consortium on Health and Ageing: Network of Cohorts in Europe and the United States (CHANCES)

Start date: Feb 1, 2010, End date: Jan 31, 2015,

CHANCES aims at combining and integrating on-going cohort studies in order to produce evidence on ageing-related health characteristics and determinants in Europe, and their socio-economic implications. 15 cohorts participate, covering populations from 18 EU Member States, 4 associate countries, and 3 additional countries. The combination of these different studies would lead to an integrated appr ...
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 17

 FINISHED 

The DNA damage response and breast cancer (DDRESPONSE)

Start date: Feb 1, 2011, End date: Jan 31, 2015,

We will exploit the DNA damage response (DDR) to assess and predict individual susceptibility and response focussed on breast cancer and breast cancer therapies. The 1st targeted therapy based on the DDR is inhibition of PARP by olaparib, which induces synthetic lethality in cancer cells with a specific DDR defect. Our members discovered olaparib, which is currently in Phase II trials. Its use in ...
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 6

 FINISHED 

Exploring ’synthetic lethality’ and ’synthetic viability’ to elucidate responses of breast and prostate cancer cells to DNA damage and treatment resistance (SYNvia)

Start date: Apr 1, 2012, End date: Mar 31, 2014,

The key objective of this Marie Curie project is to explore the ‘synthetic lethality’ and ‘synthetic viability’ principles applied to DNA damage response (DDR) mechanisms and help derive new therapies and/or biomarkers for personalized treatment of breast and prostate cancer. As these tumors are major causes of mortality and morbidity in Europe, and this multifaceted project in an outstanding host ...
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 1

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Collaborative Oncological Gene-environment Study (COGS)

Start date: May 1, 2009, End date: Jan 31, 2014,

The overarching goal of COGS is to identify individuals with an increased risk of breast, ovary and prostate cancer. Furthermore, we will evaluate the effect of inherited genetic variation on tumour characteristics and clinical outcome. We will do this through quantifying the role of genetic and environmental/lifestyle risk in the largest data set ever generated. In all, we will include over 200,0 ...
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 16

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INTEGRATING ARMENIA INTO ERA (INARMERA)

Start date: Jan 1, 2011, End date: Dec 31, 2013,

"Integration of the South Caucasus countries into ERA is one of the priorities of EU’s European Neighbourhood Policy. This is the objective of ERAWIDE initiative aimed at reinforcing the cooperation capacity of a prominent R&D centre in these countries by providing the possibilities to improve its research activities in the areas of thematic priorities of FP7. The government of the Republic of Arm ...
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 3

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European Study of Cohorts for Air Pollution Effects (ESCAPE)

Start date: Jun 1, 2008, End date: Nov 30, 2012,

"European policy making is hampered by considerable uncertainty about the magnitude and nature of the impacts of long term exposure to air pollution on human health. ESCAPE is a collaboration of more than 30 European cohort studies including some 900,000 subjects. It is aimed at quantifying health impacts of air pollution and at reducing uncertainty. ESCAPE will also test new hypotheses on specifi ...
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 26

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Europe against Cancer: Optimisation of the Use of Registries for Scientific Excellence in research (EUROCOURSE)

Start date: Apr 1, 2009, End date: Sep 30, 2012,

"EUROCOURSE will tackle fragmentation in the funding and usage of cancer registries in Europe. It will do so by exploring ways to link and integrate national/regional programmes aimed at supporting cancer registries and research carried out using registry data. At the same time EUROCOURSE is seeking to optimize the use of cancer registration data for the amelioration of cancer control and the stre ...
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 15

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An integrated concept of tumor metastasis: implications for therapy (TuMIC)

Start date: Apr 1, 2008, End date: Mar 31, 2012,

From many perspectives our concept of the process of metastasis is inadequate and needs to be revised. In particular, the potential impact of recent ideas about the cellular basis of tumor growth (cancer stem cells) and the establishment by remote tumors of special permissive microenvironments in target organs prior to metastasis (metastatic niches) remains to be explored. In the TuMIC project we ...
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 14

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"Apoptosis systems biology applied to cancer and AIDS. An integrated approach of experimental biology, data mining, mathematical modelling, biostatistics, systems engineering and molecular medicine" (APO-SYS)

Start date: Feb 1, 2008, End date: Jan 31, 2012,

"A Europe-wide consortium of experimental biologists, biomathematicians, biostatisticians, computer scientists and clinical scientists will team up to approach cell death pathways in health and disease, placing particular emphasis on cancer and AIDS. The consortium will create a unique database integrating existing and accumulating knowledge on lethal signal transduction pathways leading to apopto ...
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 24

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Genomic Instability in Cancer and Precancer (GENICA)

Start date: Jan 1, 2008, End date: Dec 31, 2010,

"Genomic instability is a characteristic of practically all human cancers. Recent results generated by members of this Consortium suggest that signs of genomic instability are evident from the very beginning of human cancer development, even in precancerous lesions. In these early lesions, the genomic instability affects primarily specific genomic loci, called common fragile sites. Because common ...
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 11

 FINISHED 

Prospective cohort studies of children with substantial medical diagnostic exposure (CHILD-MED-RAD)

Start date: Sep 1, 2008, End date: Nov 30, 2009,

The growing use of diagnostic X-rays and of high-dose techniques (CT, interventions) in children and adolescents is a topic of concern in radiological protection. Studies of other populations indicate that children are generally more sensitive to health effects of radiation than adults. In addition, children have a longer life-span to express any radiation-related health effect and, because of the ...
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 10